Ltbp1 (NM_019919) Mouse Untagged Clone

SKU MC224864

Ltbp1 (untagged) - Mouse latent transforming growth factor beta binding protein 1 (Ltbp1), transcript variant 1, (10ug)

Product Data

• Type: Mouse Untagged Clone
• Target Symbol: Ltbp1
• Synonyms: 9430031G15Rik; 9830146M04; b2b1000Clo; Ltbp-1; Ltbp1L; TGF-beta1-BP-1; Tgfb
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC224864 representing NM_019919; Red=Cloning site Blue=ORF Orange=Stop codon; ; TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC; GCCGCGATCGCC; ; ATGGCGGGAGCCTGGCTCAGGTGGGGTCTCCTGCTCTGGGCAGGGCTGCTAGCGTGGTCTGCGCACGGCC; GGGTGCGGAGGATCACGTACGTGGTGCGCCCGGGCCCGGGACTGCCGGCCGGAGCCTTGCCTCTGGCTGG; GCCCCCGCGGACCTTCAACGTCGCACTGGACGCCAGGTACAGCCGGAGCTCAACAGCCGCCTCCAGCCGC; GCCTTGGCTGGGCCCCCAGCCGAGCGGACCCGGCGCACCAGCCAGCCCGGCGGCGCGGCCCTGCCGGGGC; TCCGATCTCCGCTGCCACCCGAGCCCGCGCGTCCGGGGGGGCCCAGCCGGCAGCTCCACTCTAAGGCGGG; TGCTCAGACCGCGGTCACTCGCTTCGCCAAACATGGCAGGCAAGTCGTGCGCTCCCAAGTGCAGCAGGAC; GCTCAGAGCGCCGGGGGCTCCAGACTGCAGGTTCAGCAGAAGCAGCAGCTGCAGGGGATCAACGTCTGTG; GAGGGCAGTGCTGCCACGGGTGGAGTAAACCTCCTGGCTCCCAGAGGTGCACCAAACCCAGCTGTGTTCC; GCCATGCCAGAACGGAGGGATGTGTCTACGGCCTCAGCTCTGTGTGTGCAAGCCAGGGTCAAAGGGCAAA; GCCTGCGAGATCACAGCTGCCCAGGACACCATGCCGCCAGCCTTTGGAGGGCAGAATCCTGGGTCTTCGT; GGGCCCCCCTTGAGCAAGCAGCAAAACATACGTCAACCAAGAAGGCAGACACCTTGCCCAGGGTCAGTCC; AGTGGCCCAGATGACCTTGACCCTCAAGCCAAAGCCATCAATGGGACTCTCCCAGCAGATACATCCTCAA; GTTGCACCCTTATCTTCCCAGAATGTGATGATTCGGCATGGCCAGACCCAGGAGTACCTGCTCAAACCCA; AGTACTTCCCAGCCCCGAAGGTGGTCTCTGCGGAGCAATCCACCGAAGGCTCTTTCTCTTTAAGATATGG; GCAGGAGCAAGGCACGGCACCCTTTCAGGTGAGTAACCACACTGGTCGCATCAAGGTGGTCTTTACTCCG; AGCATCTGTAAAGTGACCTGCACCAAGGGCAACTGTCAGAACAGCTGCCAGAAGGGGAATACCACCACTC; TCATTAGTGAGAACGGCCATGCAGCCGACACCCTGACAGCCACGAACTTCCGAGTGGTTATTTGCCATCT; TCCGTGTATGAATGGTGGCCAGTGCAGTTCAAGGGACAAATGTCAGTGCCCTCCAAATTTCACAGGAAAG; CTTTGCCAGATCCCTGTCCTTGGTGCCAGTATGCCCAAACTCTACCAGCACGCCCAGCAGCAGGGCAAGG; CATTGGGGAGTCACGTCATCCATTCCACACATACCTTGCCTCTAACCATGACTAGCCAGCAAGGGGTCAA; AGTGAAATTCCCCCCCAACATAGTCAATATCCATGTGAAACATCCTCCCGAGGCTTCTGTCCAGATACAC; CAGGTTTCCAGGATTGACAGCCCAGGAGGCCAGAAGGTGAAGGAAGCCCAACCAGGCCAGTCCCAAGTCT; CTTACCAAGGACTTCCGGTCCAGAAGACCCAGACAGTCCATTCTACGTACTCCCACCAGCAGCTTATTCC; CCATGTGTATCCCGTGGCTGCTAAGACACAACTTGGCCGATGCTTCCAGGAAACCATTGGATCACAGTGT; GGCAAAGCGCTCCCTGGCCTTTCCAAGCAAGAGGACTGCTGTGGGACAGTGGGGACGTCCTGGGGCTTTA; ACAAATGCCAGAAGTGCCCCAAGAAACAATCCTATCATGGATATACTCAAATGATGGAATGCCTACAAGG; ATATAAACGGGTTAACAACACCTTTTGTCAAGATATTAATGAATGTCAGCTACAAGGTGTATGCCCTAAT; GGTGAGTGTTTGAATACCATGGGCAGCTACAGATGCTCCTGCAAAATGGGATTCGGGCCTGACCCTACCT; TTTCAAGTTGTGTTCCGGATCCCCCTGTGATCTCAGAAGAGAAAGGGCCCTGTTACCGCCTTGTCAGTCC; TGGAAGGCATTGTATGCACCCTCTCTCTGTTCATCTCACCAAGCAGATCTGCTGTTGTAGTGTGGGCAAG; GCCTGGGGCCCACATTGTGAGAAATGTCCCCTCCCAGGCACAGCTGCTTTTAAGGAAATCTGTCCTGGTG; GAATGGGTTATACGGTTTCTGGCGTTCATAGACGCAGGCCAATCCATCAGCATATAGGTAAAGAAGCTGT; ATATGTCAAGCCAAAGAACACTCAACCTGTTGCTAAAAGTACTCATCCTCCACCTCTCCCAGCCAAGGAA; GAGCCTGTGGAGGCCCTGACCTCCTCGTGGGAACACGGGCCGAGAGGGGCGGAGCCCGAAGTGGTAACAG; CACCTCCTGAGAAGGAAATACCTTCACTGGATCAAGAGAAAACCAGACTTGAACCTGGGCAACCCCAGCT; CTCCCCAGGGGTTTCAACTATTCATCTGCACCCACAGTTTCCAGTAGTGGTTGAAAAGACATCCCCTCCT; GTGCCTGTGGAAGTAGCTCCTGAAGCTTCCACATCCAGTGCCAGCCAAGTGATTGCTCCTACGCAAGTAA; CAGAAATCAACGAATGTACTGTGAACCCGGACATTTGCGGAGCAGGACACTGCATCAACCTGCCGGTGCG; GTATACCTGCATATGCTACGAGGGCTACAAGTTCAGTGAACAGCTGAGGAAATGTGTCGACATTGATGAA; TGTGCTCAGGTCCGGCACCTCTGCTCCCAGGGTCGCTGTGAGAACACAGAGGGAAGTTTCCTGTGTGTCT; GCCCGGCAGGGTTTATGGCCAGTGAGGAGGGTACTAACTGTATAGATGTGGATGAGTGCCTGAGGCCTGA; TATGTGTAGGGATGGCCGCTGCATCAACACCGCTGGGGCCTTCCGGTGCGAGTACTGTGACAGTGGGTAC; CGGATGTCACGGAGAGGCTACTGTGAGGATATTGATGAGTGTCTGAAGCCAAGCACTTGTCCCGAGGAAC; AGTGTGTGAACACCCCGGGCTCTTACCAGTGTGTGCCCTGCACAGAGGGGTTCCGCGGCTGGAATGGACA; ATGCCTTGATGTGGACGAGTGCCTGCAGCCAAAGGTCTGTACGAATGGTTCCTGCACCAACCTGGAAGGG; TCCTACATGTGTTCCTGCCACAGGGGCTACAGCCCCACACCAGACCATAGACACTGTCAAGATATTGATG; AATGCCAACAAGGGAATCTCTGCATGAATGGGCAGTGCAGAAATACCGATGGCTCCTTCCGGTGTACCTG; TGGACAGGGCTATCAGCTGTCAGCAGCTAAAGACCAATGTGAAGATATTGATGAATGCGAGCACCATCAC; CTCTGCTCTCACGGGCAGTGCAGGAACACAGAGGGCTCCTTCCAGTGTGTGTGCAACCAGGGTTACAGAG; CATCTGTACTTGGAGACCACTGTGAGGATATCAATGAATGCTTGGAGGACAGCAGTGTCTGCCAGGGAGG; TGACTGCATCAATACTGCGGGGTCCTATGATTGCACATGCCCGGATGGATTCCAGCTGAACGACAATAAG; GGCTGTCAAGACATTAATGAATGTGCACAGCCAGGACTCTGTGGATCTCATGGGGAGTGTCTAAACACAC; AAGGCTCCTTCCACTGTGTCTGTGAACAGGGGTTCTCCATCTCTGCCGATGGCCGTACATGCGAAGATAT; TGATGAGTGTGTTAACAACACTGTGTGTGACAGTCACGGCTTCTGTGACAACACAGCCGGCTCTTTCCGC; TGCCTCTGTTATCAGGGCTTTCAAGCCCCACAGGATGGGCAAGGGTGTGTGGATGTGAACGAGTGTGAAC; TGCTCAGTGGTGTATGTGGGGAAGCCTTCTGTGAAAACGTGGAAGGATCCTTCCTGTGTGTGTGTGCCGA; TGAGAACCAGGAGTACAGCCCCATGACTGGGCAGTGTCGCTCTCGGGTCACGGAAGATTCAGGTGTGGAT; CGTCAGCCTAGAGAAGAGAAGAAGGAGTGCTATTATAACCTCAATGATGCTAGTCTCTGTGATAATGTCC; TGGCCCCCAACGTCACCAAACAAGAGTGCTGCTGTACGTCAGGTGCCGGCTGGGGAGACAACTGTGAGAT; CTTCCCTTGCCCCGTCCAGGGAACTGCTGAGTTCACGGAAATGTGCCCTAGAGGGAAAGGTTTGGTCCCG; GCTGGAGAATCCTCTTACGACACTGGTGGCGAGAACTACAAAGATGCTGATGAATGCTTGCTGTTTGGAG; AGGAAATCTGTAAAAATGGTTACTGTTTGAACACTCAACCTGGGTATGAATGCTACTGTAAGCAAGGGAC; ATACTATGATCCTGTCAAATTACAGTGCTTTGATATGGATGAATGCCAAGACCCTAACAGTTGCATTGAC; GGCCAGTGTGTGAACACAGAGGGCTCCTACAACTGCTTTTGCACCCACCCAATGGTCCTGGATGCCTCTG; AGAAGAGATGTGTGCAACCAACTGAATCAAATGAACAAATAGAAGAGACCGATGTCTATCAAGATCTGTG; CTGGGAGCATCTGAGTGAGGAGTACGTGTGTAGCCGTCCTCTCGTAGGCAAGCAGACGACGTACACAGAA; TGCTGCTGTTTGTACGGGGAGGCTTGGGGCATGCAGTGTGCTCTGTGCCCCATGAAGGACTCAGATGACT; ATGCCCAGCTGTGCAATATCCCTGTGACTGGGCGTCGGCGGCCATATGGACGGGATGCATTGGTGGACTT; CAGTGAACAGTATGGCCCAGAAACAGACCCTTACTTCATCCAGGATCGCTTTCTAAATAGCTTTGAGGAG; CTACAGGCTGAGGAGTGTGGCATCCTCAATGGTTGTGAAAACGGCCGCTGTGTGAGAGTCCAGGAAGGAT; ACACTTGCGATTGCTTTGATGGATATCACCTGGATATGGCCAAGATGACCTGTGTCGATGTAAATGAATG; CAGCGAGCTGAATAATCGGATGTCTCTCTGCAAGAACGCCAAGTGCATTAACACAGAAGGCTCCTACAAA; TGCTTGTGTCTGCCAGGCTACATACCATCCGACAAGCCCAACTACTGTACACCCCTGAACAGCGCTTTGA; ATTTAGACAAAGAAAGTGACCTGGAGTGA; ; ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT; ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_019919
• Insert Size: 5139 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_019919.3, NP_064303.2
• RefSeq Size: 7910 bp
• RefSeq ORF: 5139 bp
• Locus ID: 268977
• UniProt ID: Q8CG19
• Cytogenetics: 17 E2
• Summary: Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Outcompeted by LRRC32/GARP for binding to LAP regulatory chain of TGF-beta.[UniProtKB/Swiss-Prot Function]; Transcript Variant: This variant (1) is the longest transcript and it encodes the longest isoform (LTBP-1L). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.