Kdr (NM_010612) Mouse Untagged Clone
$1,151.00
In Stock*
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
|---|---|
| Target Symbol | Kdr |
| Synonyms | 6130401C07; Flk-1; Flk1; Krd-1; Ly73; sVEGFR-2; VEGFR-2; VEGFR2 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Restriction Sites | SgfI-MluI | |
| ACCN | NM_010612 |
| Insert Size | 4038 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | BC020530, AAH20530 |
| RefSeq Size | 5464 bp |
| RefSeq ORF | 4038 bp |
| Locus ID | 16542 |
| UniProt ID | P35918 |
| Cytogenetics | 5 40.23 cM |
| Summary | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. Isoform 2 plays an important role as a negative regulator of VEGFA- and VEGFC-mediated lymphangiogenesis by limiting the amount of free VEGFA and/or VEGFC and by preventing their binding to FLT4. Modulates FLT1 and FLT4 signaling by forming heterodimers. Binding of vascular growth factors to isoform 1 leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, reorganization of the actin cytoskeleton and activation of PTK2/FAK1. Required for VEGFA-mediated induction of NOS2 and NOS3, leading to the production of the signaling molecule nitric oxide (NO) by endothelial cells. Phosphorylates PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1 and SRC.UniProtKB/Swiss-Prot Function |
Reviews
Documents
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| FAQs |
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Resources
"NM_010612" in other vectors (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| MG224504 | Kdr (tGFP-tagged) - Mouse kinase insert domain protein receptor (Kdr), (10ug) | 10 ug |
$789.00
$1,351.00
|
|
| MR224504 | Kdr (Myc-DDK-tagged) - Mouse kinase insert domain protein receptor (Kdr) | 10 ug |
$589.00
$1,151.00
|
|
| MR224504L1 | Lenti ORF clone of Kdr (Myc-DDK-tagged) - Mouse kinase insert domain protein receptor (Kdr) | 10 ug |
$1,451.00
|
|
| MR224504L2 | Lenti ORF clone of Kdr (mGFP-tagged) - Mouse kinase insert domain protein receptor (Kdr) | 10 ug |
$1,451.00
|
|
| MR224504L3 | Lenti ORF clone of Kdr (Myc-DDK-tagged) - Mouse kinase insert domain protein receptor (Kdr) | 10 ug |
$1,451.00
|
|
| MR224504L4 | Lenti ORF clone of Kdr (mGFP-tagged) - Mouse kinase insert domain protein receptor (Kdr) | 10 ug |
$1,451.00
|
|
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