Adgra2 (NM_054044) Mouse Untagged Clone
$1,258.00
7 Weeks*
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
|---|---|
| Target Symbol | Adgra2 |
| Synonyms | 8430414O08Rik; 9530074E10Rik; Gpr124; mKIAA1531; Tem5 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Restriction Sites | SgfI-MluI | |
| ACCN | NM_054044 |
| Insert Size | 4011 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_054044.2, NP_473385.2 |
| RefSeq Size | 5520 bp |
| RefSeq ORF | 4011 bp |
| Locus ID | 78560 |
| UniProt ID | Q91ZV8 |
| Cytogenetics | 8 A2 |
| Summary | Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:25373781, PubMed:25558062, PubMed:28803732). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (PubMed:21071672, PubMed:21282641, PubMed:21421844, PubMed:25373781, PubMed:28288111). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (By similarity). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (By similarity). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (By similarity).UniProtKB/Swiss-Prot Function |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_054044" in other vectors (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| MG222754 | Gpr124 (tGFP-tagged) - Mouse G protein-coupled receptor 124 (Gpr124), (10ug) | 10 ug |
$1,358.00
|
|
| MR222754 | Gpr124 (Myc-DDK-tagged) - Mouse G protein-coupled receptor 124 (Gpr124) | 10 ug |
$589.00
$1,158.00
|
|
| MR222754L3 | Lenti ORF clone of Gpr124 (Myc-DDK-tagged) - Mouse G protein-coupled receptor 124 (Gpr124) | 10 ug |
$1,458.00
|
|
| MR222754L4 | Lenti ORF clone of Gpr124 (mGFP-tagged) - Mouse G protein-coupled receptor 124 (Gpr124) | 10 ug |
$1,458.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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