Inppl1 (NM_010567) Mouse Untagged Clone
SKU
MC224080
Inppl1 (untagged) - Mouse inositol polyphosphate phosphatase-like 1 (Inppl1), transcript variant 1, (10ug)
$1,204.00
6 Weeks*
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
|---|---|
| Target Symbol | Inppl1 |
| Synonyms | 51C; SHIP2 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data | |
| Restriction Sites | SgfI-MluI | |
| ACCN | NM_010567 |
| Insert Size | 3774 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_010567.2, NP_034697.2 |
| RefSeq Size | 5012 bp |
| RefSeq ORF | 3774 bp |
| Locus ID | 16332 |
| UniProt ID | Q6P549 |
| Cytogenetics | 7 E2 |
| Summary | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:10958682). Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Akt activation, its absence does not affect insulin signaling or GLUT4 trafficking. Confers resistance to dietary obesity. May act by regulating AKT2, but not AKT1, phosphorylation at the plasma membrane. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation. Participates in regulation of cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3 thereby regulating membrane ruffling (By similarity). Regulates cell adhesion and cell spreading (PubMed:29749928). Required for HGF-mediated lamellipodium formation, cell scattering and spreading. Acts as a negative regulator of EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1 activation. Acts as a regulator of neuritogenesis by regulating PtdIns(3,4,5)P3 level and is required to form an initial protrusive pattern, and later, maintain proper neurite outgrowth. Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Involved in EGF signaling pathway. Upon stimulation by EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3. Plays a negative role in regulating the PI3K-PKB pathway, possibly by inhibiting PKB activity. Down-regulates Fc-gamma-R-mediated phagocytosis in macrophages independently of INPP5D/SHIP1. In macrophages, down-regulates NF-kappa-B-dependent gene transcription by regulating macrophage colony-stimulating factor (M-CSF)-induced signaling. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6. Involved in endochondral ossification (By similarity).UniProtKB/Swiss-Prot Function Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. |
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Resources
"NM_010567" in other vectors (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| MG211861 | Inppl1 (tGFP-tagged) - Mouse inositol polyphosphate phosphatase-like 1 (Inppl1) | 10 ug |
$1,295.00
|
|
| MR211861 | Inppl1 (Myc-DDK-tagged) - Mouse inositol polyphosphate phosphatase-like 1 (Inppl1), transcript variant 1 | 10 ug |
$589.00
$1,095.00
|
|
| MR211861L3 | Lenti ORF clone of Inppl1 (Myc-DDK-tagged) - Mouse inositol polyphosphate phosphatase-like 1 (Inppl1), transcript variant 1 | 10 ug |
$1,395.00
|
|
| MR211861L4 | Lenti ORF clone of Inppl1 (mGFP-tagged) - Mouse inositol polyphosphate phosphatase-like 1 (Inppl1), transcript variant 1 | 10 ug |
$1,395.00
|
|
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.