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Sorcs2 (NM_030889) Mouse Untagged Clone

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SKU
MC223772
Sorcs2 (untagged) - Mouse sortilin-related VPS10 domain containing receptor 2 (Sorcs2), (10ug)
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ORF Plasmid:
Tag Free tGFP DDK
  $1,111.00
7 Weeks*
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Type Mouse Untagged Clone
Target Symbol Sorcs2
Synonyms mKIAA1329; N28137
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
Fully Sequenced ORF
>MC223772 representing NM_030889
Red=Cloning site Blue=ORF Orange=Stop codon

CTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCCGGCGC
GCCC

ATGGCGCACCGGGGACCCCCGAGCGCCCCGAAGCGTCCTGGCCCTACTGCGCCGGACCGGAGCTTTCAGG
CTCTGCTGCCGCCGTGCTGGCCACGTTCGTGGCCGCTGCTGCTGCTGCTGCTGGTGCTGGTGGCTGCCTG
CGGAGCGATGGGGCGCTCCCCCCAGCCCGGGCGCCAGGGTCCCGGTGTGCAGATCACTAGGCTGCTGCCC
GCGGGACGCACGGAGTCCGGCGATCGCAAAGATCCACAGGCACGAGAATCAGAACCCAGCGTCCCGGGTC
TCGGTCCGGGTTCTGCTTCGGGTCCCAGCACCGATGGCGCCCCAGCTCCGGGCAAGGGGCGCAGGGCTCG
GGCGGTGCCGGTGGCCGGTGCGGCTTCGGCTTCGCGCGCACAGGTCTCGCTCATCAGCACGTCGTTCGTG
CTCAAGGGAGACGCGACGCACAACCAGGCGATGGTACACTGGACAGGAGAGAACAGCAGCGTCATCTTGA
TCCTGACAAAGTACTACCATGCAGACATGGGCAAGGTTCTGGAAAGTTCTCTGTGGAGGTCCTCAGATTT
TGGGACAACCTACACCAAGCTTACTCTCCAGCCTGGTGTCACCACTGTCATTGACAACTTCTATATCTGC
CCAGCTAACAAAAGGAAGATCATCCTGGTGAGCTCATCCCTCGGTGACCGGGAACAGAGCCTCTTCCTCA
GCACTGATGAGGGCGCCACGTTCCAGAAGTATCCTGTCCCCTTCCTTGTGGAGATGCTCCTCTTCCACCC
GAAGGAGGAGGACAAGGTGCTGGCCTACACCAAGGACAGCAAGCTGTATGTGTCATCGGACCTGGGAAAG
AAGTGGACACTTCTGCAGGAACGGGTGACCAAGGACCACGTGTTCTGGGCTGTGTCTGGGGTGGATGACG
ACCCAAACTTGGTCCACGTGGAAGCTCAGGACCTCAGTGGAGGCTATCGGTACTACACGTGTCTGATCTA
CAACTGCTCAGCCCAGCCACACATAGCACCCTTCTCCGGCCCCATTGACCGCGGGTCCCTGACCGTGCAG
GATGAGTACATCTTTTTGAAGGCAACATCAACAAACCGAACCAAGTACTATGTCTCCTATCGCCGAAGTG
ACTTTGTCCTGATGAAGCTGCCCAAGTATGCCCTGCCCAAGGACCTACAGATCATCAGCACGGATGAGCA
GCAGGTGTTTGTGGCCGTACAGGAGTGGAACCAGGTAGACACCTACAACCTGTACCAGTCAGACCTGCGT
GGGGTTCGCTATTCCCTGGTGCTGGAGAATGTGCGCAGCTCGAGGCAAGCCGAGGAGAACGTGGTCATCG
ACATCCTTGAGGTCAGAGGGGTGAAGGGAGTCTTCTTGGCAAACCAGAAAGTGGATGGCAAGGTGACCAC
AGTCATAACCTACAACAAGGGCCGTGACTGGGATTACCTGAGGCCACCCAGCACCGACATGAATGGGAAG
CCCACCAACTGCCAGCCGCCGGACTGTTACCTGCACCTGCACTTGCGGTGGGCAGACAACCCCTATGTGT
CAGGCACGGTACACACCAAGGACACTGCCCCTGGTCTCATCATGGGTGCAGGTAACCTGGGCTCACAGCT
GGTGGAGTATAAAGAGGAGATGTACATCACATCTGACTGCGGGCACACCTGGAGGCAGGTCTTTGAGGAA
GAGCACCATGTGTTGTACCTGGACCACGGTGGTGTCATTGCCGCCATCAAGGACACCTCCATCCCCCTGA
AGATCCTCAAGTTCAGCGTGGATGAGGGCCACACGTGGAGCACACACAACTTCACCAGCACCTCAGTGTT
CGTGGATGGGTTGCTGAGCGAGCCAGGGGATGAGACGCTGGTCATGACGGTCTTTGGTCACATCAGCTTC
CGCTCTGACTGGGAGCTGGTCAAGGTTGACTTCCGGCCCTCCTTCCCCCGGCAGTGTGGCGAGGATGACT
ACAGCTCCTGGGACCTCACTGACCTCCAGGGTGATCACTGCATCATGGGCCAACAGAGAAGTTACCGGAA
GAGAAAGTCCACATCCTGGTGTGTCAAGGGACGGAGCTTCACATCAGCACTCACGTCACGTGTGTGCAAG
TGCCGGGACTCCGACTTCCTCTGTGACTACGGGTTTGAGCGCTCATCTTCCTCGGAGTCCACTGCCAACA
AGTGCTCTGCCAACTTCTGGTTCAACCCTTTGTCTCCTCCTGAAGACTGTGTCTTGGGTCAGACTTACAC
TAGTAGCCTTGGGTACCGGAAGGTGGTGTCCAATGTGTGTGAAGGTGGTGTGGACCTGCAGCAGAGCCCA
GTGCAGCTGCAGTGCCCCCTCCAGGCACCCCGGGGCCTGCAGGTGAGCATCCGAGGAGAGGCAGTGGCCG
TGCGGCCTAGAGAAGATGTGCTGTTTGTGGTGCGACAGGAACAGGGTGATGTCCTGACCACTAAATATCA
GGTGGATCTTGGGGATGGCTTCAAGGCCATGTACGTGAACCTCACTCTGACAGGCGAGCCCATTCGACAT
CACTATGAGAGTCCTGGCATCTACCGAGTGTCCGTCAGGGCTGAGAACATGGCAGGCCATGATGAGGCTG
TGCTCTTTGTCCAGGTCAACTCTCCCCTGCAGGCCCTCTACCTCGAGGTAGTTCCTGTCATTGGCGTCAA
CCAGGAGGTGAACCTCACAGCCGTGCTGTTACCCCTGAATCCCAACCTCACTGTCTTCTACTGGTGGATC
GGCCACAGCTTGCAGCCTCTGCTTTCCTTGGACAACTCGGTGACAACAAAGTTTACGGACGCTGGGGATG
TGCGTGTGACAGTGCAAGCTGCCTGCGGGAACTCAGTGCTTCAGGACTCCAGGCTCGTCCGTGTGCTCGA
TCAGTTCCAGGTGGTGCCTCTGCGGTTCTCCAGGGAGCTGGACACCTTTAACCCCAACACTCCTGAATGG
AGGGAAGATGTGGGACTGGTGGTCACCCGACTGCTCTCCAAGGAGACCAGCATCCCAGAGGAGCTGCTTG
TGACTGTGGTAAAGCCAGGGCTGCCCACCATAGCCGACTTGTATGTGCTTCTGCCTCTGCCAAGGCCCAC
AAGGAAGAGGAGCCTCACAAGTGACAAGAGACTGGCAGCCGTGCAGCAGGCGCTGAACTCTCATAGAATC
AGCTTCATCCTTCGAGGAGGGCTTCGTATCCTGGTGGAGCTGAGGGACACAGACACAGGTCCTCAGAGGC
CAGGTGGCAGTGGTGGCTACTGGGCCGTGGTGGTCCTCTTTGTCATTGGGCTCTTTGCAGTAGGAGCATT
CATCCTCTACAAGTTCAAAAGGAAACGTCCAGGCAGGACAGTGTACGCCCAGATGCACAATGAGAAGGAA
CAGGAGATGACAAGTCCCGTGAGTCACAGTGAGGATGCCCAGAGCACCATGCAGGGCAACCACTCAGGGG
TGGTCCTGAGCATCAACTCTCGTGAGATGCATAGCTACCTGGTGGGCTGA

ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
ACAAGGATGACGACGATAAGGTTTAA
Restriction Sites AscI-MluI |
ACCN NM_030889
Insert Size 3480 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_030889.2, NP_112151.2
RefSeq Size 5722 bp
RefSeq ORF 3480 bp
Locus ID 81840
UniProt ID Q9EPR5
Cytogenetics 5 B3
Summary The heterodimer formed by NGFR and SORCS2 functions as receptor for the precursor forms of NGF (proNGF) and BDNF (proBDNF) (PubMed:22155786, PubMed:24908487, PubMed:27457814, PubMed:29909994). ProNGF and proBDNF binding both promote axon growth cone collapse (in vitro) (PubMed:24908487). Plays a role in the regulation of dendritic spine density in hippocampus neurons (PubMed:29909994). Required for normal neurite branching and extension in response to BDNF (PubMed:27457814, PubMed:29909994). Plays a role in BDNF-dependent hippocampal synaptic plasticity (PubMed:29909994, PubMed:27457814). Together with NGFR and NTRK2, is required both for BDNF-mediated synaptic long-term depression and long-term potentiation (PubMed:27457814). ProNGF binding promotes dissociation of TRIO from the heterodimer, which leads to inactivation of RAC1 and/or RAC2 and subsequent reorganization of the actin cytoskeleton (By similarity). Together with the retromer complex subunit VPS35, required for normal expression of GRIN2A at synapses and dendritic cell membranes (PubMed:28469074). Required for normal expression of the amino acid transporter SLC1A1 at the cell membrane, and thereby contributes to protect cells against oxidative stress (PubMed:30840898).UniProtKB/Swiss-Prot Function
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Documents
Resources
"NM_030889" in other vectors (4)
SKU Description Size Price
MG216425 Sorcs2 (tGFP-tagged) - Mouse sortilin-related VPS10 domain containing receptor 2 (Sorcs2), (10ug) 10 ug
$1,210.00
MR216425 Sorcs2 (Myc-DDK-tagged) - Mouse sortilin-related VPS10 domain containing receptor 2 (Sorcs2) 10 ug
$589.00 $1,010.00
MR216425L3 Lenti ORF clone of Sorcs2 (Myc-DDK-tagged) - Mouse sortilin-related VPS10 domain containing receptor 2 (Sorcs2) 10 ug
$1,310.00
MR216425L4 Lenti ORF clone of Sorcs2 (mGFP-tagged) - Mouse sortilin-related VPS10 domain containing receptor 2 (Sorcs2) 10 ug
$1,310.00

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