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Epha4 (NM_007936) Mouse Untagged Clone

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SKU
MC222938
Epha4 (untagged) - Mouse Eph receptor A4 (Epha4), (10ug)
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ORF Plasmid:
Tag Free tGFP DDK
  $994.00
5 Weeks*
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Type Mouse Untagged Clone
Target Symbol Epha4
Synonyms 2900005C20Rik; AI385584; Cek8; Hek8; rb; Sek; Sek1; Tyro1
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
Fully Sequenced ORF
>MC222938 representing NM_007936
Red=Cloning site Blue=ORF Orange=Stop codon

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGGCTGGGATTTTCTATTTCATCCTCTTTTCGTTTCTCTTTGGAATTTGCGACGCTGTCACCGGTTCTA
GGGTATACCCCGCGAATGAAGTTACTTTATTGGATTCCAGATCTGTTCAGGGAGAGCTTGGGTGGATAGC
AAGCCCTCTGGAAGGAGGGTGGGAGGAAGTGAGCATTATGGATGAGAAAAATACACCGATCCGAACCTAC
CAGGTGTGCAACGTGATGGAAGCCAGCCAGAACAACTGGCTGCGAACTGACTGGATCACCCGCGAAGGGG
CGCAGAGGGTGTACATTGAAATTAAGTTCACTCTAAGGGACTGCAACAGTCTTCCGGGCGTCATGGGGAC
TTGCAAGGAGACGTTTAACCTCTACTACTATGAGTCGGACAACGACAAGGAGCGCTTCATCAGAGAGAGC
CAGTTTGGCAAGATCGACACCATCGCAGCTGATGAGAGCTTCACGCAGGTGGACATTGGTGACCGAATCA
TGAAACTCAACACTGAGATCCGGGATGTAGGGCCACTGAGCAAGAAAGGGTTTTACCTGGCTTTTCAGGA
TGTGGGTGCTTGCATCGCCCTGGTGTCTGTCCGTGTGTTCTACAAGAAGTGTCCACTCACCGTTCGAAAT
CTAGCCCAGTTTCCTGATACCATTACTGGGGCTGATACCTCTTCCCTGGTGGAAGTTCGAGGCTCCTGTG
TCAACAACTCAGAAGAGAAGGATGTGCCAAAAATGTACTGTGGGGCAGATGGTGAATGGCTGGTACCCAT
TGGCAACTGCCTATGCAACGCTGGGCACGAGGAGCAGAATGGTGAATGCCAAGCTTGCAAAATTGGATAT
TACAAAGCTCTTTCCACGGACGCCTCCTGTGCCAAGTGTCCACCGCACAGCTACTCTGTCTGGGAAGGAG
CCACGTCCTGCACCTGTGACCGAGGCTTTTTCAGAGCTGACAACGATGCAGCCTCCATGCCCTGCACCCG
CCCACCATCTGCTCCCCTCAACTTGATTTCTAATGTCAACGAGACATCGGTGAACTTGGAATGGAGCAGC
CCTCAGAACACAGGTGGCCGTCAGGACATTTCTTACAACGTGGTCTGCAAGAAATGTGGAGCTGGTGATC
CCAGCAAGTGCCGGCCCTGTGGAAGTGGAGTCCACTACACACCACAGCAGAACGGACTCAAGACGACCAG
AGTCTCCATCACTGACCTCCTAGCACACACCAATTACACGTTTGAGATCTGGGCAGTGAATGGAGTGTCT
AAGTATAACCCTAGCCCGGACCAGTCCGTGTCTGTCACAGTGACAACCAACCAAGCAGCACCATCATCCA
TTGCTTTGGTCCAGGCTAAAGAAGTTACAAGATATAGCGTAGCTCTGGCTTGGCTGGAACCAGATCGACC
AAATGGAGTCATCTTAGAATATGAAGTCAAATATTATGAAAAGGATCAGAATGAACGCAGCTATCGCATA
GTCCGGACAGCTGCCAGGAACACAGATATCAAAGGCCTGAACCCTCTGACTTCCTATGTTTTTCACGTGC
GAGCCAGGACCGCTGCTGGCTACGGAGACTTCAGCGAGCCCCTGGAAGTCACTACTAATACAGTGCCTTC
CCGCATCATTGGCGATGGAGCCAACTCCACTGTCCTGCTGGTCTCCGTCTCTGGCAGTGTGGTCCTCGTG
GTCATTCTCATTGCAGCTTTTGTGATCAGCCGAAGACGGAGTAAGTACAGCAAAGCGAAACAAGAAGCAG
ATGAAGAGAAACATTTGAATCAAGGTGTTAGAACTTATGTGGATCCCTTTACATACGAAGACCCCAACCA
GGCAGTTCGAGAATTTGCCAAAGAAATCGATGCATCCTGCATTAAAATTGAAAAGGTCATAGGAGTTGGT
GAATTTGGAGAGGTCTGCAGTGGGCGTCTCAAAGTGCCCGGCAAGAGAGAGATCTGTGTGGCCATCAAGA
CTCTGAAAGCTGGCTATACTGACAAGCAGAGGAGAGACTTCCTGAGTGAGGCCAGCATCATGGGACAGTT
TGACCACCCAAACATAATCCACCTGGAAGGCGTTGTCACCAAATGTAAACCGGTAATGATCATAACGGAG
TACATGGAGAACGGCTCCTTGGATGCTTTCCTCAGGAAGAATGATGGCCGCTTTACAGTCATTCAGCTGG
TGGGCATGCTCCGGGGCATTGGCTCGGGGATGAAGTACTTATCTGATATGAGCTATGTGCATCGAGACCT
GGCTGCCAGGAACATCCTGGTAAACAGCAACTTGGTCTGCAAGGTGTCTGACTTTGGCATGTCCAGGGTG
CTGGAGGATGACCCCGAAGCAGCCTACACTACCAGGGGTGGCAAGATTCCTATCCGGTGGACTGCGCCAG
AAGCAATTGCGTATCGTAAATTTACCTCAGCCAGTGATGTCTGGAGCTACGGAATCGTTATGTGGGAAGT
GATGTCATATGGAGAGAGACCGTACTGGGATATGTCCAATCAAGATGTGATCAAAGCCATCGAGGAAGGG
TACCGGCTACCCCCTCCAATGGACTGCCCCATTGCCCTCCATCAGTTAATGCTGGACTGCTGGCAGAAAG
AGAGAAGTGACAGGCCTAAATTTGGGCAGATCGTCAACATGCTGGACAAACTCATCCGCAATCCCAACAG
CCTGAAGAGGACAGGGTCGGAGAGTTCCAGACCAAACACAGCCTTGTTAGATCCCAGCTCCCCTGAATTC
TCTGCTGTAGTATCAGTGGGCGACTGGCTGCAGGCCATCAAAATGGACCGGTATAAGGACAACTTCACGG
CCGCCGGGTACACGACACTAGAAGCCGTGGTTCACATGAGCCAGGACGACCTGGCGAGAATTGGCATCAC
CGCCATCACGCACCAGAATAAGATTTTGAGCAGCGTCCAGGCGATGCGAACCCAGATGCAGCAGATGCAT
GGCAGGATGGTTCCTGTCTGA

ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
ACAAGGATGACGACGATAAGGTTTAA
Restriction Sites SgfI-MluI |
ACCN NM_007936
Insert Size 2961 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_007936.3, NP_031962.2
RefSeq Size 6328 bp
RefSeq ORF 2961 bp
Locus ID 13838
UniProt ID Q03137
Cytogenetics 1 39.55 cM
Summary Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium.UniProtKB/Swiss-Prot Function
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"NM_007936" in other vectors (4)
SKU Description Size Price
MG211389 Epha4 (tGFP-tagged) - Mouse Eph receptor A4 (Epha4) 10 ug
$1,103.00
MR211389 Epha4 (Myc-DDK-tagged) - Mouse Eph receptor A4 (Epha4) 10 ug
$589.00 $903.00
MR211389L3 Lenti ORF clone of Epha4 (Myc-DDK-tagged) - Mouse Eph receptor A4 (Epha4) 10 ug
$1,203.00
MR211389L4 Lenti ORF clone of Epha4 (mGFP-tagged) - Mouse Eph receptor A4 (Epha4) 10 ug
$1,203.00

file-alt Citations

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