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Cblb (NM_001033238) Mouse Untagged Clone

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SKU
MC222751
Cblb (untagged) - Mouse Casitas B-lineage lymphoma b (Cblb), (10ug)
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ORF Plasmid:
Tag Free tGFP DDK
  $946.00
5 Weeks*
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Type Mouse Untagged Clone
Target Symbol Cblb
Synonyms AI429560; AI851073; Cbl-b
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
Fully Sequenced ORF
>MC222751 representing NM_001033238
Red=Cloning site Blue=ORF Orange=Stop codon

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGGCAAATTCTATGAATGGCAGAAATCCTGGTGGTCGAGGAGGAAACCCCCGCAAAGGTCGCATTTTGG
GGATTATTGATGCTATTCAGGATGCAGTCGGACCCCCAAAGCAAGCTGCAGCTGACCGCAGGACTGTGGA
GAAGACTTGGAAACTCATGGACAAAGTGGTAAGACTGTGCCAAAATCCCAAGCTTCAGTTGAAAAACAGC
CCACCGTATATACTTGATATTTTACCTGATACGTATCAGCACTTGAGACTTATATTGAGTAAATATGATG
ACAACCAGAAGCTGGCTCAACTGAGCGAGAATGAGTACTTTAAAATCTACATCGATAGTCTCATGAAGAA
GTCGAAGCGAGCGATCCGGCTCTTTAAAGAAGGCAAGGAAAGGATGTACGAAGAGCAGTCGCAGGACAGA
CGGAATCTCACAAAGCTGTCCCTTATCTTCAGTCACATGCTGGCAGAAATCAAGGCGATCTTTCCCAATG
GCCAGTTCCAGGGAGATAACTTCCGGATCACCAAAGCAGATGCTGCTGAGTTCTGGAGGAAGTTTTTTGG
AGACAAAACTATTGTACCATGGAAAGTCTTCAGACAGTGCCTGCATGAGGTCCATCAGATCAGCTCTGGC
CTGGAAGCAATGGCTCTGAAGTCAACCATTGATTTAACTTGCAATGATTACATCTCAGTGTTTGAATTTG
ATATTTTTACCAGGCTATTTCAGCCCTGGGGCTCTATTTTACGGAATTGGAACTTCTTGGCTGTGACTCA
CCCGGGATACATGGCATTTCTCACGTATGATGAAGTTAAAGCTCGGCTACAGAAATACAGCACCAAGCCT
GGAAGTTACATTTTCCGGTTAAGCTGCACTCGGCTGGGACAATGGGCCATTGGCTATGTGACTGGGGACG
GCAATATCCTACAGACCATACCTCATAACAAGCCCCTGTTCCAAGCCCTGATTGATGGTAGCAGGGAAGG
CTTTTATCTTTATCCTGATGGGCGGAGCTATAACCCTGATTTAACCGGATTATGTGAACCTACACCTCAC
GATCATATAAAAGTTACACAGGAGCAGTATGAACTGTATTGTGAAATGGGCTCCACTTTTCAGCTCTGCA
AGATCTGTGCAGAGAATGACAAAGATGTCAAGATTGAGCCTTGCGGGCATCTGATGTGCACTTCGTGCCT
TACCGCGTGGCAGGAGTCTGATGGCCAAGGCTGCCCCTTCTGTCGCTGTGAGATAAAAGGAACGGAGCCC
ATCATTGTGGACCCCTTCGACCCCAGAGATGAAGGCTCCAGGTGCTGCAGCATCATTGACCCTTTCAGCA
TCCCCATGCTTGACTTGGACGATGACGATGATCGAGAGGAGTCTTTGATGATGAACAGGCTGGCGAGTGT
TCGAAAGTGCACGGACAGGCAGAACTCACCAGTCACATCGCCAGGCTCCTCACCCCTTGCCCAGAGAAGA
AAGCCTCAGCCAGACCCTCTCCAGATCCCCCACCTCAGCCTGCCACCAGTGCCTCCCCGCCTAGATCTCA
TTCAGAAAGGCATCGTGCGCTCTCCGTGTGGCAGCCCCACAGGCTCGCCAAAGTCTTCTCCATGCATGGT
TAGAAAACAAGACAAACCACTCCCGGCACCCCCTCCTCCCTTGAGAGATCCACCTCCTCCACCAGAGAGG
CCTCCCCCCATCCCACCTGACAATAGACTGAGCAGACACTTCCACCATGGAGAGAGTGTGCCTTCCCGGG
ACCAGCCCATGCCCCTCGAAGCCTGGTGCCCTCGGGATGCCTTCGGGACTAACCAGGTGATGGGATGTCG
CATCCTCGGGGATGGCTCTCCAAAGCCTGGCGTCACCGCAAACTCCAGCTTAAATGGGAGGCACAGTAGA
ATGGGCTCCGAGCAGGTTCTTATGAGGAAACACAGACGCCATGATTTGCCTTCAGAAGGAGCCAAGGTCT
TTTCCAATGGCCACCTTGCCACTGAAGAATACGATGTCCCTCCTCGGCTTTCCCCTCCGCCTCCAGTCAC
CACCCTTCTCCCAAGCATAAAGTGTACTGGTCCATTAGCAAATTGTCTCTCAGAGAAAACTAGAGACACG
GTAGAAGATGATGACGATGAATACAAGATTCCTTCATCCCATCCTGTGTCCCTGAATTCACAACCATCTC
ATTGCCATAATGTCAAAGCTCCTGTTCGGTCTTGTGATAATGGTCATTGTATATTGAATGGAACTCATGG
TGCGCCTTCAGAGATGAAGAAATCGAACATCCCAGATTTAGGCATCTATTTGAAGGGTGAGGACGCCTTT
GATGCTCTCCCTCCATCCCTCCCTCCTCCCCCACCTCCTGCAAGACACAGTCTCATCGAACATTCAAAAC
CTCCAGGCTCCAGTAGCCGGCCTTCCTCAGGGCAGGACCTTTTCCTTCTTCCTTCAGATCCCTTTTTTGA
CCCAACAAGTGGCCAAGTTCCATTGCCTCCTGCCAGGAGAGCAGCAGGAGACAGCGGCAAAGCCAACAGA
GCCTCGCAGGACTATGACCAGCTCCCTTCATCTTCCGATGGTTCGCAAGCACCAGCTAGACCCCCCAAAC
CACGACCCCGAAGGACTGCACCAGAAATTCATCACAGAAAGCCCCATGGGCCCGAAGCGGCGTTGGAAAA
TGTCGATGCAAAAATTGCAAAACTCATGGGAGAGGGGTATGCCTTTGAAGAGGTGAAGAGAGCCTTAGAG
ATTGCCCAGAATAACGTGGAAGTGGCCAGGAGCATACTTCGAGAATTTGCCTTCCCCCCTCCTGTCTCCC
CACGTCTGAATCTATAG

ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
ACAAGGATGACGACGATAAGGTTTAA
Restriction Sites SgfI-MluI |
ACCN NM_001033238
Insert Size 2817 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_001033238.1, NP_001028410.1
RefSeq Size 6323 bp
RefSeq ORF 2817 bp
Locus ID 208650
UniProt ID Q3TTA7
Cytogenetics 16 B5
Summary E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (PubMed:29237719).UniProtKB/Swiss-Prot Function
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"NM_001033238" in other vectors (4)
SKU Description Size Price
MG227649 Cblb (tGFP-tagged) - Mouse Casitas B-lineage lymphoma b (Cblb), (10ug) 10 ug
$1,059.00
MR227649 Cblb (Myc-DDK-tagged) - Mouse Casitas B-lineage lymphoma b (Cblb) 10 ug
$589.00 $859.00
MR227649L3 Lenti ORF clone of Cblb (Myc-DDK-tagged) - Mouse Casitas B-lineage lymphoma b (Cblb) 10 ug
$1,159.00
MR227649L4 Lenti ORF clone of Cblb (mGFP-tagged) - Mouse Casitas B-lineage lymphoma b (Cblb) 10 ug
$1,159.00

file-alt Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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