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Cbl (NM_007619) Mouse Untagged Clone

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SKU
MC222572
Cbl (untagged) - Mouse Casitas B-lineage lymphoma (Cbl), (10ug)
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ORF Plasmid:
Tag Free tGFP DDK
  $920.00
5 Weeks*
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Type Mouse Untagged Clone
Target Symbol Cbl
Synonyms 4732447J05Rik; c-Cbl; Cbl-2
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
Fully Sequenced ORF
>MC222572 representing NM_007619
Red=Cloning site Blue=ORF Orange=Stop codon

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGGCCGGCAACGTGAAGAAGAGCTCGGGCGCCGGCGGCGGCGGCTCTGGGGGCTCGGGAGCGGGCGGCC
TGATCGGGCTCATGAAGGACGCCTTCCAGCCGCACCACCACCACCACCACCTCAGCCCGCACCCTCCCTG
CACGGTGGACAAGAAGATGGTGGAGAAGTGCTGGAAGCTCATGGACAAGGTGGTGCGGTTGTGTCAAAAC
CCAAAGCTGGCGCTCAAGAACAGCCCGCCTTATATCTTAGACCTGCTGCCTGACACCTACCAGCACCTCC
GCACTGTCTTGTCAAGATATGAGGGGAAGATGGAGACGCTTGGAGAAAATGAGTATTTCAGGGTGTTCAT
GGAAAATTTGATGAAGAAAACTAAGCAGACTATCAGCCTCTTCAAGGAGGGAAAAGAAAGGATGTATGAG
GAGAATTCCCAGCCTAGGCGAAACCTGACCAAATTATCCCTGATCTTCAGCCACATGCTGGCAGAACTGA
AAGGCATCTTTCCGAGCGGACTCTTCCAAGGAGACACTTTCCGGATTACTAAAGCTGATGCTGCCGAATT
TTGGAGAAAAGCTTTTGGTGAAAAGACGATAGTCCCGTGGAAGAGCTTTCGACAGGCCCTGCATGAAGTG
CATCCCATCAGTTCTGGGCTGGAGGCCATGGCTCTGAAGTCCACTATTGATCTGACCTGCAATGATTATA
TTTCTGTCTTTGAATTTGATATTTTTACACGGCTGTTTCAGCCCTGGTCCTCTTTGCTCAGAAATTGGAA
CAGCCTTGCTGTAACTCACCCTGGTTACATGGCTTTCCTGACATACGATGAAGTGAAAGCGCGCCTGCAG
AAGTTCATCCACAAACCTGGCAGTTACATCTTTCGGCTGAGCTGTACTCGTTTGGGTCAGTGGGCTATTG
GGTATGTTACTGCCGATGGGAACATTCTGCAGACAATCCCACACAATAAACCGCTCTTCCAAGCACTGAT
TGATGGCTTCAGGGAAGGCTTCTATTTGTTTCCTGATGGACGAAATCAAAATCCTGACCTGACAGGTTTA
TGTGAACCAACTCCTCAAGATCATATCAAAGTAACCCAGGAACAATATGAATTATACTGTGAAATGGGCT
CCACATTTCAACTGTGTAAGATATGTGCTGAGAATGATAAGGATGTGAAGATTGAGCCCTGTGGACACCT
CATGTGCACATCCTGCCTCACGTCGTGGCAGGAATCAGAAGGTCAGGGCTGTCCTTTTTGCCGATGTGAA
ATCAAAGGTACTGAGCCCATCGTGGTGGATCCGTTTGACCCCAGAGGCAGTGGCAGCCTATTAAGGCAAG
GAGCAGAAGGTGCTCCTTCCCCAAATTACGACGATGATGATGATGAACGAGCTGATGATTCTCTCTTCAT
GATGAAGGAGTTGGCAGGTGCCAAGGTGGAAAGGCCTTCCTCTCCATTCTCCATGGCCCCACAAGCTTCC
CTTCCTCCAGTGCCACCAAGACTTGACCTTCTACAGCAGCGAGCACCTGTTCCTGCCAGCACTTCAGTTC
TGGGGACTGCTTCCAAGGCTGCTTCTGGCTCCCTTCATAAAGACAAACCATTGCCAATACCTCCCACACT
TCGAGATCTTCCACCACCACCCCCTCCAGACCGGCCTTACTCTGTTGGAGCAGAAACAAGGCCTCAGAGA
CGCCCTCTGCCTTGTACACCAGGCGATTGTCCATCTAGAGACAAACTGCCCCCTGTCCCTTCTAGCCGCC
CAGGGGACTCGTGGTTGTCTCGGCCAATCCCTAAAGTACCAGTAGCTACTCCAAACCCTGGTGATCCTTG
GAATGGGAGAGAATTGACCAATCGGCACTCGCTTCCATTCTCATTGCCCTCACAAATGGAACCCAGAGCA
GATGTCCCTAGGCTTGGAAGCACATTTAGTCTGGATACCTCTATGACTATGAATAGCAGCCCAGTAGCAG
GTCCAGAGAGTGAGCACCCAAAGATCAAGCCTTCCTCGTCTGCCAACGCCATTTACTCTCTGGCTGCCAG
GCCTCTTCCTATGCCAAAACTGCCACCTGGGGAGCAAGGGGAAAGTGAAGAGGACACAGAATATATGACT
CCCACATCTAGGCCTGTAGGGGTTCAGAAGCCAGAGCCCAAACGGCCGTTAGAGGCAACCCAGAGTTCAC
GAGCATGTGACTGTGACCAGCAGATCGACAGCTGTACCTATGAAGCGATGTATAACATCCAGTCCCAAGC
ACTGTCTGTAGCAGAAAACAGCGCCTCTGGGGAAGGGAATCTGGCCACAGCTCACACGAGTACTGGCCCT
GAGGAATCCGAAAACGAGGATGATGGCTATGATGTGCCTAAGCCACCCGTGCCAGCTGTACTGGCCCGCC
GGACCCTGTCTGACATCTCCAATGCCAGCTCCTCCTTTGGCTGGTTGTCTTTGGATGGTGACCCTACAAA
CTTCAATGAGGGTTCCCAAGTTCCTGAGCGGCCCCCCAAACCATTCCCTCGGAGAATCAACTCAGAACGA
AAAGCCAGTAGCTATCAACAAGGCGGAGGTGCCACTGCTAACCCTGTGGCCACAGCACCCTCACCGCAGC
TCTCAAGTGAGATTGAACGCCTCATGAGTCAGGGCTATTCCTACCAGGACATTCAGAAAGCTTTGGTCAT
TGCCCACAACAACATTGAGATGGCTAAAAACATCCTCCGGGAATTTGTTTCTATTTCTTCTCCTGCTCAC
GTAGCCACCTAG

ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
ACAAGGATGACGACGATAAGGTTTAA
Restriction Sites SgfI-MluI |
ACCN NM_007619
Insert Size 2742 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_007619.2, NP_031645.2
RefSeq Size 5083 bp
RefSeq ORF 2742 bp
Locus ID 12402
UniProt ID P22682
Cytogenetics 9 24.72 cM
Summary Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-737' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3 (PubMed:10393178, PubMed:12649282, PubMed:19265199, PubMed:20100865, PubMed:9653117). In association with CBLB, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (PubMed:29237719).UniProtKB/Swiss-Prot Function
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"NM_007619" in other vectors (4)
SKU Description Size Price
MG227679 Cbl (tGFP-tagged) - Mouse Casitas B-lineage lymphoma (Cbl), (10ug) 10 ug
$789.00 $1,036.00
MR227679 Cbl (Myc-DDK-tagged) - Mouse Casitas B-lineage lymphoma (Cbl) 10 ug
$589.00 $836.00
MR227679L3 Lenti ORF clone of Cbl (Myc-DDK-tagged) - Mouse Casitas B-lineage lymphoma (Cbl) 10 ug
$1,136.00
MR227679L4 Lenti ORF clone of Cbl (mGFP-tagged) - Mouse Casitas B-lineage lymphoma (Cbl) 10 ug
$1,136.00

file-alt Citations

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