Il31ra (NM_139299) Mouse Untagged Clone

CAT#: MC221042

Il31ra (untagged) - Mouse interleukin 31 receptor A (Il31ra), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Il31ra
• Synonyms: CRL3; GLM-R; Glmr; GPL; NR10
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC221042 representing NM_139299
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGTGGACCTTGGCACTGTGGGCATTCTCTTTCCTCTGCAAATTCAGCCTGGCAGTCCTGCCGACTAAGC
  CAGAGAACATTTCCTGCGTCTTTTACTTCGACAGAAATCTGACTTGCACTTGGAGACCAGAGAAGGAAAC
  CAATGATACCAGCTACATTGTGACTTTGACTTACTCCTATGGAAAAAGCAATTATAGTGACAATGCTACA
  GAGGCTTCATATTCTTTTCCCCGTTCCTGTGCAATGCCCCCAGACATCTGCAGTGTTGAAGTACAAGCTC
  AAAATGGAGATGGTAAAGTTAAATCTGACATCACATATTGGCATTTAATCTCCATAGCAAAAACCGAACC
  ACCTATAATTTTAAGTGTGAATCCAATTTGTAATAGAATGTTCCAGATACAATGGAAACCGCGTGAAAAG
  ACTCGTGGGTTTCCTTTAGTATGCATGCTTCGGTTCAGAACTGTCAACAGTAGCCACTGGACGGAAGTCA
  ATTTTGAAAACTGTAAACAGGTCTGCAACCTCACAGGACTTCAGGCTTTCACAGAATATGTCCTGGCTCT
  ACGATTCAGGTTCAATGACTCAAGATATTGGAGCAAGTGGAGCAAAGAAGAAACCAGAGTGACTATGGAG
  GAAGTTCCACATGTCCTGGACCTGTGGAGAATTCTGGAACCAGCAGACATGAACGGAGACAGGAAGGTGC
  GATTGTTGTGGAAGAAGGCAAGAGGAGCCCCCGTCTTGGAGAAAACATTTGGCTACCACATACAGTACTT
  TGCAGAGAACAGCACTAACCTCACAGAGATAAACAACATCACCACCCAGCAGTATGAACTGCTTCTGATG
  AGCCAGGCACACTCTGTGTCCGTGACTTCTTTTAATTCTCTTGGCAAGTCCCAAGAGGCCATCCTGAGGA
  TCCCAGATGTCCATGAGAAGACCTTCCAGTACATTAAGAGCATGAAGGCCTACATAGCCGAGCCCCTGTT
  GGTGGTGAACTGGCAAAGCTCCATTCCTGCGGTGGACACTTGGATAGTGGAGTGGCTCCCAGAAGCTGCC
  ATGTCGAAGTTCCCTGCCCTTTCCTGGGAATCTGTGTCTCAGGTCACGAACTGGACCATCGAGCAAGATA
  AACTAAAACCTTTCACATGCTATAATATATCAGTGTATCCAGTGTTGGGACACCGAGTTGGAGAGCCGTA
  TTCAATCCAAGCTTATGCCAAAGAAGGAACTCCATTAAAAGGTCCTGAGACCAGGGTGGAGAACATCGGT
  CTGAGGACAGCCACGATCACATGGAAGGAGATTCCTAAGAGTGCTAGGAATGGATTTATCAACAATTACA
  CTGTATTTTACCAAGCTGAAGGTGGAAAAGAACTCTCCAAGACTGTTAACTCTCATGCCCTGCAGTGTGA
  CCTGGAGTCTCTGACACGAAGGACCTCTTATACTGTTTGGGTCATGGCCAGCACCAGAGCTGGAGGTACC
  AACGGGGTGAGAATAAACTTCAAGACATTGTCAATCAGTGTGTTTGAAATTGTCCTTCTAACATCTCTAG
  TTGGAGGAGGCCTTCTTCTACTTAGCATCAAAACAGTGACTTTTGGCCTCAGAAAGCCAAACCGGTTGAC
  TCCCCTGTGTTGTCCTGATGTTCCCAACCCTGCTGAAAGTAGTTTAGCCACATGGCTCGGAGATGGTTTC
  AAGAAGTCAAATATGAAGGAGACTGGAAACTCTGGGGACACAGAAGACGTGGTCCTAAAACCATGTCCCG
  TCCCCGCGGATCTCATTGACAAGCTGGTAGTGAACTTTGAGAATTTTCTGGAAGTAGTTTTGACAGAGGA
  AGCTGGAAAGGGTCAGGCGAGCATTTTGGGAGGAGAAGCGAATGAGTATGTGACCTCCCCGTCTAGGCCC
  GACGGTCCCCCAGGGAAAAGTTTTAAAGAGCCCTCCGTTTTAACTGAGGTTGCTTCTGAAGACTCCCACA
  GCACGTGTTCCAGAATGGCGGACGAGGCGTACTCAGAATTGGCCAGGCAGCCTTCGTCTTCCTGTCAGAG
  TCCAGGGCTATCGCCTCCCCGTGAAGACCAAGCTCAGAATCCATATTTGAAAAATTCAGTGACAACCAGG
  GAATTTCTTGTGCATGAGAATATCCCAGAGCACAGCAAAGGAGAAGTCTGA
  
  ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
  ACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-MluI
• ACCN: NM_139299
• Insert Size: 2151 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_139299.2, NP_647460.2
• RefSeq Size: 3680 bp
• RefSeq ORF: 2151 bp
• Locus ID: 218624
• UniProt ID: Q8K5B1
• Cytogenetics: 13 D2.2
• Gene Summary: Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity (PubMed:15184896). Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (PubMed:24373353). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (PubMed:17379091).[UniProtKB/Swiss-Prot Function]