Kmo (NM_133809) Mouse Untagged Clone
SKU
MC216699
Kmo (untagged) - Mouse kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) (Kmo), (10ug)
$732.00
In Stock*
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
|---|---|
| Target Symbol | Kmo |
| Synonyms | AI046660 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Restriction Sites | SgfI-MluI | |
| ACCN | NM_133809 |
| Insert Size | 1440 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_133809.1, NP_598570.1 |
| RefSeq Size | 2512 bp |
| RefSeq ORF | 1440 bp |
| Locus ID | 98256 |
| UniProt ID | Q91WN4 |
| Cytogenetics | 1 H3 |
| Summary | Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.UniProtKB/Swiss-Prot Function |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_133809" in other vectors (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| MG207671 | Kmo (tGFP-tagged) - Mouse kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) (Kmo) | 10 ug |
$886.00
|
|
| MR207671 | Kmo (Myc-DDK-tagged) - Mouse kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) (Kmo) | 10 ug |
$686.00
|
|
| MR207671L3 | Lenti ORF clone of Kmo (Myc-DDK-tagged) - Mouse kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) (Kmo) | 10 ug |
$986.00
|
|
| MR207671L4 | Lenti ORF clone of Kmo (mGFP-tagged) - Mouse kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) (Kmo) | 10 ug |
$986.00
|
|
Citations
Development of LC/MS/MS, High-Throughput Enzymatic and Cellular Assays for the Characterization of Compounds That Inhibit Kynurenine Monooxygenase (KMO)
Winkler, Beconi, Toledo-Sherman et al
J Biomol Screen (2013) 18 (8), 879-89 DOI: 10.1177/1087057113489731
Winkler, Beconi, Toledo-Sherman et al
J Biomol Screen (2013) 18 (8), 879-89 DOI: 10.1177/1087057113489731
Cited by 15
AI Summary: OriGene contributed human, rat, and mouse KMO complementary DNAs (cDNAs), which were used to express KMO for the development and characterization of biochemical and cellular assays in this study.
Snippet: Complementary DNAs (cDNAs) encoding human, rat, and mouse KMO were purchased from Origene (Rockville, MD). ... Alexa Fluor 555 goat anti–rabbit IgG A21429 (1:1000 dilution;Life Technologies, Darmstadt, Germany) was used as a secondary antibody.
Showing 1-1 of 1 papers.
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