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Set (NM_023871) Mouse Untagged Clone

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SKU
MC210017
Set (untagged) - Mouse SET nuclear oncogene (Set), transcript variant 1, (10ug)
Interest in protein/lysate? Submit request here!
ORF Plasmid:
Tag Free tGFP DDK
AAV Particle:
DDK
  $300.00
In Stock*
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Type Mouse Untagged Clone
Target Symbol Set
Synonyms 2610030F17Rik; 5730420M11Rik; AA407739; I-2PP2A; StF-IT-1; TAF-I
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
Fully Sequenced ORF
>NCBI ORF sequence for NM_023871, the custom clone sequence may differ by one or more nucleotides


ATGGCCCCGAAGCGGCAGTCTGCGATCCTGCCTCAGCCCAAGAAACCCAGACCGGCTGCTGCCCCGAAGC
TGGAGGACAAGTCGGCCTCTCCCGGCCTGCCGAAGGGAGAAAAAGAACAGCAAGAAGCAATTGAACATAT
TGATGAAGTACAAAATGAAATAGACAGACTTAATGAACAAGCCAGTGAGGAAATTTTGAAAGTAGAACAA
AAATATAACAAACTCCGCCAACCATTTTTTCAGAAGAGGTCAGAATTGATCGCCAAAATCCCAAATTTTT
GGGTAACAACATTTGTCAACCATCCACAAGTGTCTGCACTGCTTGGGGAGGAGGACGAGGAGGCTCTGCA
TTATTTGACCAGAGTTGAAGTGACAGAATTTGAAGACATTAAATCAGGTTACAGAATAGATTTTTATTTT
GATGAAAATCCTTACTTTGAAAATAAAGTTCTCTCCAAAGAATTTCATCTGAATGAGAGTGGTGACCCGT
CTTCAAAGTCCACCGAAATCAAATGGAAATCTGGAAAGGATTTGACAAAACGCTCAAGTCAAACGCAAAA
TAAGGCCAGCAGGAAGAGGCAGCACGAAGAGCCAGAGAGCTTCTTTACCTGGTTTACTGACCATTCTGAC
GCAGGTGCTGATGAGTTAGGAGAGGTCATCAAAGATGACATCTGGCCAAATCCCTTGCAGTACTACCTGG
TTCCCGACATGGATGATGAAGAAGGAGAGGCAGAAGATGATGATGACGACGACGAAGAGGAGGAGGGGCT
GGAAGATATTGATGAAGAAGGAGATGAGGATGAAGGTGAAGAAGATGACGATGAGGATGAAGGGGAGGAA
GGAGAGGAGGACGAAGGCGAGGATGATTAG
Restriction Sites SgfI-MluI |
ACCN NM_023871
Insert Size 870 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq BC018255, AAH18255
RefSeq Size 1884 bp
RefSeq ORF 870 bp
Locus ID 56086
UniProt ID Q9EQU5
Cytogenetics 2 B
Summary Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher (By similarity).UniProtKB/Swiss-Prot Function
Transcript Variant: This variant (1) encodes the longer isoform (1; also known as isoform alpha).
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Documents
Resources
"NM_023871" in other vectors (4)
SKU Description Size Price
MG223300 Set (tGFP-tagged) - Mouse SET translocation (Set), (10ug) 10 ug
$500.00
MR223300 Set (Myc-DDK-tagged) - Mouse SET nuclear oncogene (Set), transcript variant 1 10 ug
$289.00 $300.00
MR223300L3 Lenti ORF clone of Set (Myc-DDK-tagged) - Mouse SET nuclear oncogene (Set), transcript variant 1 10 ug
$600.00
MR223300L4 Lenti ORF clone of Set (mGFP-tagged) - Mouse SET nuclear oncogene (Set), transcript variant 1 10 ug
$600.00

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