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Cops4 (NM_012001) Mouse Untagged Clone

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SKU
MC209745
Cops4 (untagged) - Mouse COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana) (Cops4), (10ug)
Interest in protein/lysate? Submit request here!
ORF Plasmid:
Tag Free tGFP DDK
AAV Particle:
DDK
  $503.00
3 Weeks*
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Specifications
Specifications
Product Data
Type Mouse Untagged Clone
Target Symbol Cops4
Synonyms AW208976; D5Ertd774e; SGN4
Vector pCMV6-Entry
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
Fully Sequenced ORF
>MC209745 representing NM_012001
Red=Cloning site Blue=ORF Orange=Stop codon

TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
GCCGCGATCGCC

ATGGCGGCTGCCGTGCGACAGGATTTGGCCCAGCTCATGAATTCAAGCGGCTCTCATAAAGATCTGGCGG
GCAAATATCGTCAGATTCTGGAAAAAGCCATTCAGTTATCTGGGACAGAACAACTAGAAGCATTGAAAGC
TTTTGTGGAAGCGATGGTGAATGAGAATGTCAGCCTCGTGATCTCACGGCAACTGCTAACAGATTTCTGC
ACACACCTCCCTAACCTGCCAGACAGCACAGCCAAGGAGGTCTACCATTTCACCTTGGAGAAGATCCAGC
CTCGGGTCATTTCCTTTGAAGAGCAGGTTGCTTCCATAAGACAGCATCTGGCATCTATTTATGAGAAGGA
GGAAGACTGGAGAAATGCAGCCCAAGTGTTGGTGGGGATTCCTCTGGAAACAGGACAAAAACAGTACAAC
GTAGATTATAAGCTGGAGACTTACCTGAAGATTGCAAGGCTATACCTGGAGGATGACGATCCCGTCCAGG
CCGAGGCTTACATAAACCGAGCGTCCTTACTTCAGAACGAATCCACAAATGAACAGTTACAGATACACTA
TAAGGTTTGCTATGCGCGTGTCCTTGATTACAGAAGGAAATTCATTGAGGCCGCCCAGAGGTACAATGAG
CTCTCTTACAAGACAATAGTCCATGAAAGTGAGAGACTAGAGGCCTTAAAGCATGCACTGCACTGCACCA
TCTTAGCATCGGCAGGACAGCAGCGCTCTCGGATGCTGGCTACTCTTTTTAAGGATGAAAGGTGCCAGCA
ACTAGCTGCATATGGGATCCTAGAGAAGATGTACCTAGACAGAATCATCAGAGGGAACCAGCTTCAAGAA
TTTGCTGCTATGCTGATGCCACACCAAAAAGCAACGACAGCTGATGGTTCCAGCATCTTGGACAGAGCTG
TTATTGAGCATAATTTGTTGTCAGCAAGCAAATTATATAACAATATCACCTTTGAAGAACTTGGAGCTCT
TTTAGAGATCCCTGCAGCTAAGGCAGAAAAGATAGCATCTCAGATGATAACGGAAGGACGCATGAATGGG
TTTATTGACCAGATCGATGGAATAGTTCATTTTGAAACACGAGAAGCCCTGCCAACATGGGACAAGCAGA
TCCAGTCACTTTGTTTCCAAGTAAACAACCTCCTGGAGAAAATTAGTCAGACGGCCCCGGAGTGGACAGC
ACAAGCCATGGAAGCGCAGATGGCCCAGTGA

ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT
ACAAGGATGACGACGATAAGGTTTAA
Restriction Sites SgfI-MluI |
ACCN NM_012001
Insert Size 1221 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_012001.2, NP_036131.1
RefSeq Size 1771 bp
RefSeq ORF 1221 bp
Locus ID 26891
UniProt ID O88544
Cytogenetics 5 48.49 cM
Summary Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).UniProtKB/Swiss-Prot Function
Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
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Documents
Resources
"NM_012001" in other vectors (4)
SKU Description Size Price
MG217112 Cops4 (tGFP-tagged) - Mouse COP9 (constitutive photomorphogenic) homolog subunit 4 (Arabidopsis thaliana) (Cops4), (10ug) 10 ug
$657.00
MR217112 Cops4 (Myc-DDK-tagged) - Mouse COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana) (Cops4) 10 ug
$289.00 $457.00
MR217112L3 Lenti ORF clone of Cops4 (Myc-DDK-tagged) - Mouse COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana) (Cops4) 10 ug
$757.00
MR217112L4 Lenti ORF clone of Cops4 (mGFP-tagged) - Mouse COP9 (constitutive photomorphogenic) homolog, subunit 4 (Arabidopsis thaliana) (Cops4) 10 ug
$757.00

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