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Casp2 (NM_007610) Mouse Untagged Clone

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SKU
MC206011
Casp2 (untagged) - Mouse caspase 2 (Casp2), (10ug)
Interest in protein/lysate? Submit request here!
ORF Plasmid:
Tag Free tGFP DDK
  $686.00
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Specifications
Specifications
Product Data
Type Mouse Untagged Clone
Target Symbol Casp2
Synonyms Casp; CASP-2; Ich-; ICH-1; Nedd; NEDD-2; Nedd2
Vector PCMV6-Kan/Neo
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
Fully Sequenced ORF
>BC034262
TGGGGGAGGGATGCGGGGGCTGGCGCGGCCCAGCGTTTGTTTGTTTTGTGGGTGGTGCGTGTGCAGCCCG GGAAAAGCTGGAAATGGCGGCGCCGAGCGGGAGGTCGCAGTCCTCCCTGCACAGGAAGGGGCTGATGGCG GCTGACAGGAGGAGCAGGATTTTGGCAGTGTGTGGAATGCATCCTGACCACCAGGAAACACTGAAAAAGA ATCGAGTGGTGCTGGCCAAGCAGCTGCTGCTGAGCGAGCTGTTAGAACACCTCCTAGAGAAGGACATTAT CACTTTGGAAATGAGGGAGCTCATCCAGGCCAAAGGGGGCAGTTTCAGCCAGAATGTGGAACTCCTCAAC CTGCTGCCAAAGAGAGGACCCCAGGCTTTTGATGCCTTCTGTGAAGCCCTGCGGGAGACCAGGCAGGGTC ACTTGGAAGACTTACTGCTCACAACCCTCTCAGATATTCAGCACGTACTCCCACCGTTGAGCTGTGACTA TGACACAAGTCTCCCTTTCTCGGTGTGTGAGTCCTGCCCTCCTCACAAGCAGCTCCGCCTATCCACAGAT GCTACGGAACACTCCTTAGATAATGGTGATGGTCCTCCCTGTCTTCTGGTGAAGCCATGCACTCCTGAGT TTTACCAGGCACACTACCAGCTGGCCTATAGGTTGCAATCTCAGCCCCGTGGCTTGGCACTGGTGCTGAG CAATGTGCACTTCACTGGAGAGAAAGACCTGGAATTCCGCTCTGGAGGGGATGTGGACCACACTACTCTA GTCACCCTCTTCAAGCTTTTGGGCTACAATGTCCATGTGCTACATGACCAGACCGCACAGGAAATGCAAG AGAAACTTCAGAATTTTGCACAGTTACCTGCACACCGGGTCACAGACTCCTGCGTAGTGGCACTCCTCTC ACATGGTGTGGAAGGTGGCATCTATGGTGTAGATGGCAAACTGCTTCAGCTCCAAGAGGTTTTTCGACTT TTTGACAATGCTAACTGTCCAAGTCTACAGAACAAGCCAAAAATGTTCTTCATCCAAGCATGTCGTGGAG ATGAGACAGATAGAGGTGTCGACCAGCAAGATGGAAAGAACCACACACAATCCCCTGGATGTGAGGAGAG TGATGCTGGCAAAGAGGAGTTGATGAAGATGAGACTGCCTACTCGCTCAGACATGATATGTGGCTATGCT TGCCTTAAAGGTAATGCTGCCATGCGGAACACCAAACGGGGTTCCTGGTACATTGAGGCCCTCACTCAGG TGTTCTCTGAAAGAGCTTGTGACATGCACGTGGCCGACATGCTTGTTAAGGTGAATGCCCTTATCAAGGA GCGTGAAGGCTATGCCCCTGGCACAGAATTCCACCGATGCAAGGAGATGTCTGAGTACTGTAGTACTCTG TGCCAGCAACTCTACCTGTTCCCAGGCTACCCACCCACGTGATGCCGCCTGCTATTCCTGCTGTTGGAGG CCACTGGACCACTGGGGGCACAATGGAGACTTCTCTTCAGAATGGTTTTTGTTCTGTCTACCCTCTCAGG GATATGAGATTCTCCCAGGCTTGTTTCCTGTCAGCCATCTCTGTCTTTGGGTATGAAACATAAGGATGGC TCCTCCGGTGTCGTGTTCTCTACCTATAGAGCCAGCTCTGAATGGATATGTTACCAGAAGCATTTTAGCT ACAGCCTAGAAAATGACATTGTGAACACAGTATTATTGTGGGAAAAGGGCATTTGGATTTCTCAATGTTT GTGATATTTTTGTTCCCAAGGCATCTTAGGAGTACTTGGATCATAGCTTTTTTTTTTTTTCCTAAATCAG TTAAGGAGTCTCAGAGATCATCTCCTTTTTTTTCCATATCTACAACCTCATTTTTCCCACAGTGGAGATT TGGAAGCTGTCCCAATTTAATGTAGGTGTTTTCATCTGTCATGAAGGGACAGATGAGATCCTACTACTTG CGAAGTTTCTATGCATACCTTTAAGTTCAGGCCCTAGGTGAAGGACAGTCCCTCAGCCTTTCCATTGGTT CCTTTGTGTTCAGTGCACCCAGCCTTTGAACAGAGCCTAGGGTCTGTATGCCATGACACTGGAAGTCATA GAAATTTCCCTGGTCATGCTTTGTTTGAACTGTCACTGAATGAACCTTATCGGGCATAACTACATGAAAA TGCAGTGACAGCTGAGTGTGCTGTGTCTCACACTATCACCCGTCATCAGGATGTCTCTCCTTCCTTACTG TGGCTTCTGCATGCACTTACACTGTACTTGACGGCTGGCCTCCAGGGTCTCTCTTGCTTTGTACTGGTTC CCCTCTTTACCTTCACCATTCGCTGCTTCTGCCAAGTCTGTGAAGCCGTCCTTTGTAGGATGTTTCTTGC CACTTACGCTGTACTGTAGTTGCTTATTCATTCTGCCTTCTGCTTCAGCGTGAGGCTTCTTTGGTTTTCT GTGGCAGCGTCTCCCTTCTCATTGTTTCTCTGTGTTTTAGTGGGGATAGTACCATATGTGATATAACCTA GAAGCACTTGTCTCTGCTCTTATGAAACTTGCTTATTCTTGAAAACCTTCTGCATTTCCATTTTTTCCTC TCTTCCAATTTATTCTCCATGTAACAGAGTAGTTTGGTTTTTAAAATATCTGGTGATGTCATTCTCTTGC TTAGAACACTAGCTTCCTGTTACACTTCATCTAAAATGCAAATTCTTACACCCAGCTTACGAGATCTGGC TCATACCTTCCCTTTGGATCTCATTAAATGGTGATTTCTCACTATGCTCCAGCCCCTCTTAGGTCCTCAT CTCCGTCTTGCAGGTGTTCTGAACTCTCCTTTGGCTAGTCTCTGATTTTTGAGTCTGGCGGAGGCCTCTT GACCATGCTGCCCATGCTGTCTACTGTGCCTCCTTATGAGGGCATCATGTTGGTCTCTGTTGTGCTTACT GCAGGCTGTAATGGCACTTTTGCTTGTTTCACTTGTTCCCTCTGAGGCTGAATGCTCCAAGAGAGTGGGA ACTGTGCTTCTTACTTACTGATATCCAGTAACTGGCACTTACTAGGTCTTCATGAATGTTTCCTGAGTAA AGGAAGGAGACCAGCAGCTAACCTTAGTTAGAGCCTACCTTTTGCAGTTTCTAAATTGCTATTATAGTGT ACAGTTCAATTAGTATATGGGTTTTTTTTTCCAGGTGTTTTATTTTTATCCACTGTTTTGTTGTTGTTTT TTTATATTTTCTACATATCACGTGTGAGACAACTTCTTTCACATCTCCATAGTGCCCAGCAAATTTGAGG CCTATGGTAGTTGAGGTGCTCAACTAATGTTTGTTGTATGAACCAAGTGGTTTGAAGACTTGCTGCCAAA TTCTGCCTTTTGGGTCAGTATAGGATGCATAAGTGGTAGAATCTTCACACTTCCCACTGCCAAGATTTTG TATTGCCATCAGGTGCCAAATAAATGTTGATACTTATTACTGAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAA
Restriction Sites RsrII-NotI |
ACCN NM_007610
Insert Size 1359 bp
OTI Disclaimer Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.

The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq BC034262, AAH34262
RefSeq Size 3503 bp
RefSeq ORF 1359 bp
Locus ID 12366
UniProt ID P29594
Cytogenetics 6 20.54 cM
Summary This gene encodes the evolutionarily ancient and most conserved member of the cysteine proteases that plays important role in stress-induced apoptosis, DNA repair and tumor suppression. Mice lacking the encoded protein develop normally but display cell type-specific apoptotic defects. Germ cells and oocytes from such mice were found to be resistant to cell death after treatment with chemotherapeutic drugs. provided by RefSeq, Apr 2015
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"NM_007610" in other vectors (4)
SKU Description Size Price
MG207227 Casp2 (tGFP-tagged) - Mouse caspase 2 (Casp2) 10 ug
$886.00
MR207227 Casp2 (Myc-DDK-tagged) - Mouse caspase 2 (Casp2) 10 ug
$686.00
MR207227L3 Lenti ORF clone of Casp2 (Myc-DDK-tagged) - Mouse caspase 2 (Casp2) 10 ug
$986.00
MR207227L4 Lenti ORF clone of Casp2 (mGFP-tagged) - Mouse caspase 2 (Casp2) 10 ug
$986.00

file-alt Citations

ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P
Kim, Garcia-Carbonell, Yamachika et al
Cell (2018) 175 (1), 133-145.e15 DOI: 10.1016/j.cell.2018.08.020
Cited by 343
AI Summary: In this study, OriGene’s Caspase-2 shRNA lentiviral particles (TL502832) and Caspase-2 overexpression plasmid (RC207771) were used to modulate Caspase-2 expression in cell-based experiments, enabling the authors to investigate its role in ER stress-driven lipogenesis and the progression of steatohepatitis.
Figure
Showing 1-1 of 1 papers.
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