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Parn (NM_028761) Mouse Untagged Clone

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SKU
MC203133
Parn (untagged) - Mouse poly(A)-specific ribonuclease (deadenylation nuclease) (Parn), (10ug)
Interest in protein/lysate? Submit request here!
ORF Plasmid:
Tag Free tGFP DDK
AAV Particle:
DDK
  $582.00
In Stock*
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Specifications
Specifications
Product Data
Type Mouse Untagged Clone
Target Symbol Parn
Synonyms 1200003I18Rik; DAN
Vector PCMV6-Kan/Neo
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
Fully Sequenced ORF
>BC021899
GTGCTGTTTCGTGGCGGCCTCCGACATCCCCACGCTGCTTTTGCTGCGGAACTCTGCGCGTGGACCGGCG TCAGCCTGGGCGGGGCCAAGGTTCCGTCTGCGCCGCAGGATGGAGATAATCCGGAGCAATTTTAAGATTA ATCTTCACAAAGTGTACCAGGCCATAGAGGAGGCTGACTTCTTCGCCATCGATGGGGAGTTTTCAGGAAT CAGCGATGGACCCTCAGTAACAGCATTAACAAGTGGTTTTGACACCCCAGAAGAGAGATATCAGAAGCTT AAAAAGCATTCCATGGACTTTTTGCTGTTTCAGTTTGGCCTTTGTGCTTTTAAGTATGACCACACAGATT CCAAGCATGTAACGAAGTCATTTAACTTCTATGTTTTCCCCAAGCCTTTCAGTAGGTCCTCACCAGATGT CAAGTTTGTTTGCCAGAGCTCCAGCATTGACTTCCTGGCGAGCCAAGGATTTGACTTTAATAAAGTGTTT TGCAGTGGGATTCCATATCTGAATCAGGAAGAAGAAAGGCAGCTGAGAGAGCAATTCGATGAAAAACGGT CTCAAGCCAATGGGGCAGGAGCTCTGGCAAAATGTCCTGTGACCATCCCTGAGGATCAGAAGAAGTTTAT TGACCAAGTAATAGAGAAGATAGAGGATTTCCTACAAAGTGAAGAGAAGAGGAGCCTGGAACTTGACCCA TGCACTGGGTTCCAAAGAAAACTTATTTATCAGACTTTGAGTTGGAAGTATCCTAAAGGCATTCATGTTG AGACATTAGAGACTGACAAGAAGGAAAGACATATAGTTATCAGCAAGGTGGATGAAGAAGAACGCAAAAG GAGAGAGCAGGAGAAGTATACAAAGGAACAGGAGGAGCTGAATGATGCTGTGGGGTTTTCAAGAGTCATC CATGCCATTGCTAATTCGGGGAAGCTGGTTGTGGGACACAACATGCTCTTGGATGTCATGCATACGATTC ATCAGTTCTACTGCCCCCTGCCTGCGGACCTGAATGAGTTTAAGGAGATGGCAATATGTGTCTTCCCCAG ACTCTTGGATACTAAGTTGATGGCCAGCACACAGCCTTTTAAGGATATCATTAACAACACATCCCTTGCA GAGTTGGAAAAGCGGTTGAAAGAGACACCTTTTGACCCTCCCAAAGTTGAAAGTGCAGAAGGCTTTCCAA GCTACGACACAGCTTCTGAGCAGCTTCATGAGGCGGGGTACGATGCCTACATCACAGGGCTCTGCTTCAT CTCCATGGCAAATTACTTAGGTTCTTTACTCAGTCCTCCAAAAATGTGTGTGTCTGCCAGATCAAAGCTC ATTGAACCCTTTTTTAACAAGTTATTTCTTATGAGGGTCATGGATATTCCCTATTTAAACTTGGAAGGGC CAGACTTGCAGCCTAAGCGGGACCATGTTCTCCACGTGACCTTCCCCAAAGAGTGGAAAACCAGCGACCT GTACCAGCTCTTCAGCGCCTTCGGTAACATTCAGATATCCTGGATTGATGATACATCAGCCTTCGTTTCT CTCAGCCAGCCAGAACAAGTACAAATTGCCGTTAATACCAGCAAGTACGCTGAAAGTTATCGGATCCAGA CCTATGCTGAGTATGTGGGAAAGAAGCAGGAAGGCAAGCAGGTCAAGAGGAAGTGGACAGAAGACAGTTG GAAGGAGGTGGACAGAAAGCGGCCCCACATGCAGGGCCCCTGTTACCACAGCAACAGCTTCACAGCAGCT GGCGTGCTTGGAAAGAGAACGCTGAGTCCTGACCCAAGGGAAGCTGCCTTGGAGGACAGAGAATCAGAGG AGGTATCTGACTCGGAGCTTGAACAGACAGATTCCTGTACAGACCCCCTCCCAGAGGGAAGGAAAAAGTC CAAGAAGTTAAAACGAATGAAGAAGGAGCTTTCCTTGGCAGGAAGTGTCTCGGATAGCCCTGCCGTGCTC TTTGAAGTCCCTGACACATGGTAGTGGAGTACTGCTGCGACAGCCCAGCCTACCTGCTTGGAAGCCATAC TGTAGACACTTAACCAGATATGGCCTGGGGGAGTTTTGGAACCAGATTGTTTCCTGCAAAGCTACTTTTT ACTGTTTTGGCTGCATCTATTGTCCCTTTTAGTCTAAACTGACCTTTGGCACACGTCGTGGTTGAGGGCT TCTGCAAGCGTGTGTGTTATTAACTAATTACTTCCTGCTCCTTGAAAACCTGCCTGCCCTGGTGAATGTT GGCAAGTCCACCCAGGGAGTAAGTCAGCTGTGAACCACGCCAGGAGAGCCAACCTCCGGGGTGTTCTAGG CAGATTTCTGCAGAGCTTCTCCTGCCCGAGATGTGCCCTGCCATCCTCCCACTGCTGCCCTGAAACAGCA CACAGGCTTGTCTTTTCAGTGGGAGATTCCTGTGCTAGCTCAGGCTCATCTCAACAGATGCCCAGGCTTT GAGAGCTTGTTATTTCAAGTTTCTTTCCCTCAGATAGGAGTGTGTCCCGGGTGTGGTGACATGTGTGTGA GAAGCTGGCTCTTCTGTTCCTACGCACAGGGTTCACGGTGCAGCAGCTTCTCCTGGTTTTTACTGTATGT CTTTGTGCATCTGTATCTGGGTACATGGTGTGTGTGTCTGTCTCTGTGTGTGTATGTGTCTGTGTGTGTG TCTGTCTGTCTGTCTGTGACAGTGGCAGGCCTACAGCATGCATCAAGTCCTCACTCAGACAGGTTTCAGT GGCAGAGCCTCACTTGCTCCTGCAGGATACCCCACAGCAGACACTTCTGGACATGTAACGCTTTTGTATC ATGAAAATAAAAGTGAAAAAGTAATTTCAAAAAGCTGAAATTAAAGAAAATTTCCTAGAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Restriction Sites RsrII-NotI |
ACCN NM_028761
Insert Size 1875 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq BC021899, AAH21899
RefSeq Size 2900 bp
RefSeq ORF 1875 bp
Locus ID 74108
UniProt ID Q8VDG3
Cytogenetics 16 A1
Summary 3'-exoribonuclease that has a preference for poly(A) tails of mRNAs, thereby efficiently degrading poly(A) tails. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs and is also used to silence certain maternal mRNAs translationally during oocyte maturation and early embryonic development. Interacts with both the 3'-end poly(A) tail and the 5'-end cap structure during degradation, the interaction with the cap structure being required for an efficient degradation of poly(A) tails. Involved in nonsense-mediated mRNA decay, a critical process of selective degradation of mRNAs that contain premature stop codons. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3' UTR, possibly via its interaction with KHSRP. Probably mediates the removal of poly(A) tails of AREs mRNAs, which constitutes the first step of destabilization (By similarity). Also able to recognize poly(A) tails of microRNAs such as MIR21 and H/ACA box snoRNAs (small nucleolar RNAs) leading to leading to microRNAs degradation or snoRNA increased stability (By similarity).UniProtKB/Swiss-Prot Function
Transcript Variant: This variant (1) encodes the longest isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.
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"NM_028761" in other vectors (4)
SKU Description Size Price
MG209527 Parn (tGFP-tagged) - Mouse poly(A)-specific ribonuclease (deadenylation nuclease) (Parn) 10 ug
$782.00
MR209527 Parn (Myc-DDK-tagged) - Mouse poly(A)-specific ribonuclease (deadenylation nuclease) (Parn) 10 ug
$289.00 $582.00
MR209527L3 Lenti ORF clone of Parn (Myc-DDK-tagged) - Mouse poly(A)-specific ribonuclease (deadenylation nuclease) (Parn) 10 ug
$882.00
MR209527L4 Lenti ORF clone of Parn (mGFP-tagged) - Mouse poly(A)-specific ribonuclease (deadenylation nuclease) (Parn) 10 ug
$882.00

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