E Cadherin (CDH1) Mouse Monoclonal Antibody [Clone ID: UMAB184]

CAT#: UM800076CF

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Carrier-free (BSA/glycerol-free) CDH1 mouse monoclonal antibody,clone UMAB184



  View other "UMAB184" antibodies (2)

USD 528.00


Availability*
4 Weeks

Size
    • 100 ug


Specifications

Product Data
Clone Name UMAB184
Applications 10k-ChIP, FC, IF, IHC, WB
Recommended Dilution IHC 1:100~200
Reactivity Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen The extracellular domain of human CDH1 (NP_004351) produced in human cells.
Formulation Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 94.8 kDa
Gene Name Homo sapiens cadherin 1 (CDH1), transcript variant 1, mRNA.
Background This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008]
Synonyms Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways Adherens junction, Bladder cancer, Cell adhesion molecules (CAMs), Endometrial cancer, Melanoma, Pathogenic Escherichia coli infection, Pathways in cancer, Thyroid cancer

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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