EPCAM Mouse Monoclonal Antibody [Clone ID: UMAB131]
Specifications
| Product Data | |
| Clone Name | UMAB131 |
|---|---|
| Application | FC, IHC, WB |
| Recommended Dilution | WB 1:1000, IHC 1:200 |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human EPCAM(NP_002345) produced in HEK293T cell. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 0.5~1.0 mg/ml (Lot Dependent) |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | epithelial cell adhesion molecule |
| Database Link | |
| Background | This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. provided by RefSeq, Dec 2008 |
| Synonyms | DIAR5; EGP-2; EGP40; EGP314; ESA; HNPCC8; KS1/4; KSA; M4S1; MIC18; MK-1; TACSTD1; TROP1 |
| Reference Data | |
| Protein Categories | ADC Targets, Cancer: Gastrointestinal, CAR-T Targets, CD Markers, Intracellular Proteins, Membrane Proteins |
| Protein Families | ES Cell Differentiation/IPS, Transmembrane |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "UMAB131" antibodies (2)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| UM500096 | EPCAM mouse monoclonal antibody,clone UMAB131 | 100 ul |
$610.00
|
|
| UM500096CF | Carrier-free (BSA/glycerol-free) EPCAM mouse monoclonal antibody,clone UMAB131 | 100 ug |
$680.00
|
|
Citations
Optimal Cannabinoid-Terpene Combination Ratios Suppress Mutagenicity of Gastric Reflux in Normal and Metaplastic Esophageal Cells
Goldman, Gonzalez, Karpova et al
bioRxiv (2025)
Goldman, Gonzalez, Karpova et al
bioRxiv (2025)
AI Summary: OriGene's anti-epithelial cell adhesion molecule (EPCAM, cat# UM500096) antibody was used as a primary antibody in immunostaining experiments to assess protein expression in esophageal cell models and patient samples in this study.
Snippet: Blocking solution consisting of 10% normal donkey serum in PBS (EMD Millipore, S30-100 ML, Billerica, MA, USA) was added to the slides and left for 30 minutes at room temperature. The blocking solution was replaced with the primary antibodies diluted in blocking solution using rabbit anti-CB1 (clone D5N5C, Cell Signaling Technologies, cat# 93815, Massachusetts, USA) and anti-epithelial cell adhesion molecule (EPCAM) (Origene, cat# UM500096, Maryland, USA),
Regulation of epithelial migration by epithelial cell adhesion molecule requires its Claudin-7 interaction domain
Barth, Kim, Riedel-Kruse
PLoS ONE (2018) 13 (10), e0204957 DOI: 10.1371/journal.pone.0204957
Barth, Kim, Riedel-Kruse
PLoS ONE (2018) 13 (10), e0204957 DOI: 10.1371/journal.pone.0204957
AI Summary: OriGene’s anti-EpCAM antibody (UMAB131) was used to assess EpCAM protein levels by immunoblotting in MDCK cell lines with altered EpCAM expression, enabling the study of EpCAM’s role in regulating epithelial migration.
Snippet: SH134T-mU6-01). Stable MDCK cell lines either overexpressing EpCAM or depleted of EpCAM were established by screening clonal lines for EpCAM levels by immunoblotting with anti-EpCAM antibody UMAB131 (OriGene Technologies, Inc., Rockville, MD). EpCAM-depleted MDCK line Esh2 was transfected with expression vectors for EY (EpCAM-YFP), EIY (EpCAM-YFP defective for Claudin-7 binding), or EEY (EpCAM-YFP
Showing 1-2 of 2 papers.
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