EGFR Mouse Monoclonal Antibody [Clone ID: UMAB95]
Specifications
| Product Data | |
| Clone Name | UMAB95 |
|---|---|
| Application | 10k-ChIP, IF, IHC, WB |
| Recommended Dilution | WB 1:500, IHC 1:100 |
| Reactivity | Human, Monkey, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human EGFR(NP_958440) produced in HEK293T cell. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 0.5~1.0 mg/ml (Lot Dependent) |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 42.4 kDa |
| Gene Name | epidermal growth factor receptor |
| Database Link | |
| Background | The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. provided by RefSeq, Jul 2010 |
| Synonyms | ERBB; ERBB1; ERRP; HER1; mENA; NISBD2; PIG61 |
| Reference Data | |
| Protein Categories | ADC Targets, Cancer: Bladder, Cancer: Brain and CNS, Cancer: Gastrointestinal, Cancer: Gynecologic, Cancer: Head and Neck, Cancer: Lung, CAR-T Targets, Cytokines, Enzyme: Kinases, Growth Factors, Immune system diseases, Membrane Proteins, Secreated Proteins |
| Protein Families | Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Secreted Protein, Stem cell relevant signaling - JAK/STAT signaling pathway, Transmembrane |
| Protein Pathways | Adherens junction, Bladder cancer, Calcium signaling pathway, Colorectal cancer, Cytokine-cytokine receptor interaction, Dorso-ventral axis formation, Endocytosis, Endometrial cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, GnRH signaling pathway, MAPK signaling pathway, Melanoma, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "UMAB95" antibodies (2)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| UM500070CF | Carrier-free (BSA/glycerol-free) EGFR mouse monoclonal antibody,clone UMAB95 | 100 ug |
$680.00
|
|
| UM570070 | EGFR mouse monoclonal antibody,clone UMAB95 | 30 ul |
$224.00
|
|
Citations
Critical relevance of genomic gains of PRL-3/EGFR/c-myc pathway genes in liver metastasis of colorectal cancer
Tanaka, Kaida, Yokoi et al
Oncol Lett (2019) 17 (1), 1257-1266 DOI: 10.3892/ol.2018.9728
Tanaka, Kaida, Yokoi et al
Oncol Lett (2019) 17 (1), 1257-1266 DOI: 10.3892/ol.2018.9728
AI Summary: OriGene’s Anti EGFR UltraMAB (R) UM570070 antibody was used for immunohistochemical staining to assess EGFR protein expression in liver metastases from colorectal cancer, contributing to the study’s analysis of genomic gains in the PRL-3/EGFR/c-myc pathway.
Snippet: Liver metastases from CRC were immunohistochemically stained for PRL-3, c-myc, EGFR, and E-cadherin using the following respective antibodies: anti-human/-mouse/-rat PRL-3 antibody Clone 334407, Human c-Myc Antibody Monoclonal Mouse IgG1 Clone #9E10 cat. … MAB3696 (both R&D Systems Inc., Minneapolis, MN, USA), Anti EGFR UltraMAB (R) UM570070 (OriGene Technologies Inc., Rockville, MD, USA), and G-10:sc-8426 diluted 1:200 (Santa Cruz Biotechnology, Inc., Dallas, TX, USA)
Critical relevance of genomic gains of PRL‑3/EGFR/c‑myc pathway genes in liver metastasis of colorectal cancer
Tanaka, Kaida, Yokoi et al
Oncol Lett (2018)
Tanaka, Kaida, Yokoi et al
Oncol Lett (2018)
Prediction model of lymphovascular invasion based on clinicopathological factors in Chinese patients with invasive breast cancer
Shen, Wu, Xiao et al
Medicine (Baltimore) (2018) 97 (43), e12973 DOI: 10.1097/MD.0000000000012973
Shen, Wu, Xiao et al
Medicine (Baltimore) (2018) 97 (43), e12973 DOI: 10.1097/MD.0000000000012973
Cited by 18
AI Summary: OriGene products, specifically the anti-HER-2 antibody (TA808229), anti-Ki67 antibody (TA500294), and anti-P53 antibody (TA802901), were used for immunohistochemical detection of protein expression in breast cancer tissue samples, contributing to the evaluation of clinicopathological risk factors for lymphovascular invasion in this study.
[Clinical Significance and Mechanism of PI3K p110β Overexpression
in Non-small Cell Lung Cancer]
Xiong, Qu, Li et al
Zhongguo Fei Ai Za Zhi (2017) 20 (12), 808-816 DOI: 10.3779/j.issn.1009-3419.2017.12.03
Xiong, Qu, Li et al
Zhongguo Fei Ai Za Zhi (2017) 20 (12), 808-816 DOI: 10.3779/j.issn.1009-3419.2017.12.03
Cited by 1
Showing 1-4 of 4 papers.
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