Isocitrate dehydrogenase (IDH1) Mouse Monoclonal Antibody [Clone ID: OTI24A2]
SKU
TA800426
IDH1 (Isocitrate Dehydrogenase 1) mouse monoclonal antibody, clone OTI24A2 (formerly 24A2)
$447.00
In Stock*
Specifications
| Product Data | |
| Clone Name | OTI24A2 |
|---|---|
| Application | IHC, WB |
| Recommended Dilution | WB 1:2000, IHC 1:150 |
| Reactivity | Dog, Human, Monkey, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG2b |
| Clonality | Monoclonal |
| Immunogen | Synthetic peptide around the R132 region of the human IDH conjugated to KLH |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 46.5 kDa |
| Gene Name | isocitrate dehydrogenase (NADP(+)) 1, cytosolic |
| Database Link | |
| Background | Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. provided by RefSeq, Jul 2008 |
| Synonyms | HEL-216; HEL-S-26; IDCD; IDH; IDP; IDPC; PICD |
| Reference Data | |
| Protein Categories | Cancer: Brain and CNS, Cancer: Haematopoietic and Lymphoid, Cardiovascular diseases, Intracellular Proteins |
| Protein Pathways | Citrate cycle (TCA cycle), Glutathione metabolism, Metabolic pathways |
Reviews
Documents
| Product Manuals |
| FAQs |
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Resources
Other "OTI24A2" antibodies (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF800426 | Carrier-free (BSA/glycerol-free) IDH1 mouse monoclonal antibody, clone OTI24A2 (formerly 24A2) | 100 ug |
$620.00
|
|
| TA600199 | IDH1 mouse monoclonal capture antibody, validated for ELISA and Luminex assays | 100 ug |
$458.00
|
|
| TA700199 | IDH1 biotinylated mouse monoclonal detection antibody, validated for ELISA and Luminex assays | 50 ug |
$494.00
|
|
| TA800426AM | IDH1 mouse monoclonal antibody,clone 24A2, Biotinylated | 100 ul |
$509.00
|
|
| TA800426BM | IDH1 mouse monoclonal antibody,clone 24A2, HRP conjugated | 100 ul |
$509.00
|
|
| TA800426S | IDH1 (Isocitrate Dehydrogenase 1) mouse monoclonal antibody, clone OTI24A2 (formerly 24A2) | 30 ul |
$200.00
|
|
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