E Cadherin (CDH1) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | ELISA |
|---|---|
| Recommended Dilution | WB: 1:5000-1:20000; ELISA: 1:100-1:2000 |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | DNA immunization. This antibody is specific for the N Terminus Region of the target protein. |
| Buffer | 20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0 |
| Concentration | 0.68mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | cadherin 1 |
| Database Link | |
| Background | E-Cadherin, a member of the cadherin superfamily, is implicated as a key player in different cellular processes including development, morphology, polarity, migration and tissue integrity (1-2). E-cadherin is a glycoprotein with an extracellular domain that interacts with other E-cadherin molecules on adjacent cells, thereby establishing adhesion between epithelial cells. Established as a tumor and metastasis suppressor, E-cadherin expression is frequently down-regulated or extinguished in malignancy which strongly correlates with poor prognosis (3-4). Mutations in E-cadherin are found in gastric, breast, colorectal, thyroid and ovarian cancer (5). |
| Synonyms | Arc-1; CD324; CDHE; ECAD; LCAM; UVO |
| Note | This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT |
| Reference Data | |
| Protein Categories | Cancer: Endocrine, Cancer: Gastrointestinal, Cancer: Gynecologic, Cancer: Head and Neck, CD Markers, Membrane Proteins |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
| Protein Pathways | Adherens junction, Bladder cancer, Cell adhesion molecules (CAMs), Endometrial cancer, Melanoma, Pathogenic Escherichia coli infection, Pathways in cancer, Thyroid cancer |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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