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SAMHD1 Mouse Monoclonal Antibody [Clone ID: OTI2D7]

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SKU
TA501954
SAMHD1 mouse monoclonal antibody, clone OTI2D7 (formerly 2D7)
Size:
100 ul 30 ul
Formulation:
Standard Carrier-free
Conjugation:
Unconjugated Biotin HRP
  $447.00
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View other "SAMHD1 or NM_015474" antibodies

Specifications
Specifications
Product Data
Clone Name OTI2D7
Application FC, IF
Recommended Dilution IF 1:100
FLOW 1:100
Reactivity Human
Antibody Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen Full length human recombinant protein of human SAMHD1 (NP_056289) produced in HEK293T cell.
Buffer PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 72 kDa
Gene Name SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
Database Link
Background This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. provided by RefSeq. COMPLETENESS: complete on the 3' end.
Synonyms CHBL2; DCIP; HDDC1; MOP-5; SBBI88
Reference Data
Protein Categories Immune system diseases, Intracellular Proteins
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Other "OTI2D7" antibodies (4)
SKU Description Size Price
CF501954 Carrier-free (BSA/glycerol-free) SAMHD1 mouse monoclonal antibody, clone OTI2D7 (formerly 2D7) 100 ug
$620.00
TA501954AM SAMHD1 mouse monoclonal antibody, clone OTI2D7 (formerly 2D7), Biotinylated 100 ul
$509.00
TA501954BM SAMHD1 mouse monoclonal antibody, clone OTI2D7 (formerly 2D7), HRP conjugated 100 ul
$509.00
TA501954S SAMHD1 mouse monoclonal antibody, clone OTI2D7 (formerly 2D7) 30 ul
$200.00

file-alt Citations

HIV-1 evasion of restriction factors: cyclophilin A and cell fusion provide a helping hand
Owen, Vaughan-Jackson, Nussbaum et al
bioRxiv (2018)
Snippet: Membranes were probed with mouse anti-SAMHD1 (2D7, Origene, 1:2000), rabbit 480 anti-phT592-SAMHD1 (Cell Signalling Technology, 1:1000) and rabbit anti-GAPDH (Sigma,1:5000) 481 and quantified using the Odyssey far red imager (LiCor)
WB
Inhibition of hepatitis B virus replication by a dNTPase-dependent function of the host restriction factor SAMHD1
Jeong, Park, Ahn et al
Virology (2016) 495, 71-78 DOI: 10.1016/j.virol.2016.05.001
Cited by 44
AI Summary: OriGene’s anti-SAMHD1 antibody was used in this study to detect and analyze SAMHD1 protein levels, enabling the authors to investigate its role in inhibiting hepatitis B virus replication.
Snippet: The membrane was incubated in 10 mM Tris–HCl (pH 7.6), 150 mM NaCl, 0.1% Tween 20% and 5% skim milk with an anti-SAMHD1 (Origene), anti-HA (Santa Cruz Biotechnology), anti-actin (ABGENT) or anti-MxA (prepared in this lab) antibody. ... Cite SaveSaving
WB
SAMHD1 Degradation Enhances Active Suppression of Dendritic Cell Maturation by HIV-1
Hertoghs, van der Aar, Setiawan et al
J. Immunol. (2015) 194 (9), 4431-7 DOI: 10.4049/jimmunol.1403016
Cited by 31
AI Summary: OriGene’s purified SAMHD1 antibody was used for Western blot analysis to detect and quantify SAMHD1 protein levels in dendritic cells, enabling the researchers to assess the impact of HIV-1 infection and SAMHD1 depletion on dendritic cell maturation.
Snippet: A purified SAMHD1 Ab was used for Western blot (Origene). Immunoblot. Five hundred thousand DCs were treated with three concentrations of VLP–SIV-Vpx and whole cell extracts were prepared using cell lysis buffer (Cell Signaling). ... Cite SaveSaving
WB
SAMHD1 restricts HIV-1 replication and regulates interferon production in mouse myeloid cells
Zhang, Bloch, Nguyen et al
PLoS One (2014) 9 (2), e89558 DOI: 10.1371/journal.pone.0089558
Cited by 21
AI Summary: In this paper, OriGene’s SAMHD1 shRNA (catalog # TL502431) and SAMHD1 antibody (catalog # TA500648) were used to knock down and detect SAMHD1 expression in mouse myeloid cells, enabling the study of SAMHD1’s role in restricting HIV-1 replication and regulating interferon production.
FigureFigureFigure
Showing 1-4 of 4 papers.
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