SAMHD1 Mouse Monoclonal Antibody [Clone ID: OTI2D7]
SKU
CF501954
Carrier-free (BSA/glycerol-free) SAMHD1 mouse monoclonal antibody, clone OTI2D7 (formerly 2D7)
$620.00
3 Days*
Specifications
| Product Data | |
| Clone Name | OTI2D7 |
|---|---|
| Application | FC, IF, WB |
| Recommended Dilution | WB 1:2000, IF 1:100, FLOW 1:100 |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG2b |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human SAMHD1 (NP_056289) produced in HEK293T cell. |
| Buffer | Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
| Reconstitution Method | For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific) |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Ambient |
| Predicted Protein Size | 72 kDa |
| Gene Name | SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 |
| Database Link | |
| Background | This gene may play a role in regulation of the innate immune response. The encoded protein is upregulated in response to viral infection and may be involved in mediation of tumor necrosis factor-alpha proinflammatory responses. Mutations in this gene have been associated with Aicardi-Goutieres syndrome. provided by RefSeq. COMPLETENESS: complete on the 3' end. |
| Synonyms | CHBL2; DCIP; HDDC1; MOP-5; SBBI88 |
| Reference Data | |
| Protein Categories | Immune system diseases, Intracellular Proteins |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI2D7" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| TA501954 | SAMHD1 mouse monoclonal antibody, clone OTI2D7 (formerly 2D7) | 100 ul |
$447.00
|
|
| TA501954AM | SAMHD1 mouse monoclonal antibody, clone OTI2D7 (formerly 2D7), Biotinylated | 100 ul |
$509.00
|
|
| TA501954BM | SAMHD1 mouse monoclonal antibody, clone OTI2D7 (formerly 2D7), HRP conjugated | 100 ul |
$509.00
|
|
| TA501954S | SAMHD1 mouse monoclonal antibody, clone OTI2D7 (formerly 2D7) | 30 ul |
$200.00
|
|
Citations
HIV-1 evasion of restriction factors: cyclophilin A and cell fusion provide a helping hand
Owen, Vaughan-Jackson, Nussbaum et al
bioRxiv (2018)
Owen, Vaughan-Jackson, Nussbaum et al
bioRxiv (2018)
Inhibition of hepatitis B virus replication by a dNTPase-dependent function of the host restriction factor SAMHD1
Jeong, Park, Ahn et al
Virology (2016) 495, 71-78 DOI: 10.1016/j.virol.2016.05.001
Jeong, Park, Ahn et al
Virology (2016) 495, 71-78 DOI: 10.1016/j.virol.2016.05.001
Cited by 44
AI Summary: OriGene’s anti-SAMHD1 antibody was used in this study to detect and analyze SAMHD1 protein levels, enabling the authors to investigate its role in inhibiting hepatitis B virus replication.
Snippet: The membrane was incubated in 10 mM Tris–HCl (pH 7.6), 150 mM NaCl, 0.1% Tween 20% and 5% skim milk with an anti-SAMHD1 (Origene), anti-HA (Santa Cruz Biotechnology), anti-actin (ABGENT) or anti-MxA (prepared in this lab) antibody. ... Cite SaveSaving
SAMHD1 Degradation Enhances Active Suppression of Dendritic Cell Maturation by HIV-1
Hertoghs, van der Aar, Setiawan et al
J. Immunol. (2015) 194 (9), 4431-7 DOI: 10.4049/jimmunol.1403016
Hertoghs, van der Aar, Setiawan et al
J. Immunol. (2015) 194 (9), 4431-7 DOI: 10.4049/jimmunol.1403016
Cited by 31
AI Summary: OriGene’s purified SAMHD1 antibody was used for Western blot analysis to detect and quantify SAMHD1 protein levels in dendritic cells, enabling the researchers to assess the impact of HIV-1 infection and SAMHD1 depletion on dendritic cell maturation.
Snippet: A purified SAMHD1 Ab was used for Western blot (Origene). Immunoblot. Five hundred thousand DCs were treated with three concentrations of VLP–SIV-Vpx and whole cell extracts were prepared using cell lysis buffer (Cell Signaling). ... Cite SaveSaving
SAMHD1 restricts HIV-1 replication and regulates interferon production in mouse myeloid cells
Zhang, Bloch, Nguyen et al
PLoS One (2014) 9 (2), e89558 DOI: 10.1371/journal.pone.0089558
Zhang, Bloch, Nguyen et al
PLoS One (2014) 9 (2), e89558 DOI: 10.1371/journal.pone.0089558
Cited by 21
AI Summary: In this paper, OriGene’s SAMHD1 shRNA (catalog # TL502431) and SAMHD1 antibody (catalog # TA500648) were used to knock down and detect SAMHD1 expression in mouse myeloid cells, enabling the study of SAMHD1’s role in restricting HIV-1 replication and regulating interferon production.
Showing 1-4 of 4 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
Related Products
- Price:
- Actual Price:
Welcome to OriGene AI!
I'm your AI-powered guide to everything OriGene.
Ask me anything:
- Product specs
- Ordering help
- Technical questions
- How to find exactly what your experiment needs
Prefer a live agent? Connect with us by clicking the green chat icon, as seen in the image below or email our team at custsupport@origene.com.
