Haptoglobin (HP) Mouse Monoclonal Antibody [Clone ID: OTI4H5]
$200.00
2 Days*
Specifications
| Product Data | |
| Clone Name | OTI4H5 |
|---|---|
| Application | FC, IF, WB |
| Recommended Dilution | WB 1:500, IF 1:100, FLOW 1:100 |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG2a |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human HP (NP_005134) produced in HEK293T cell. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 43.3 kDa |
| Gene Name | haptoglobin |
| Database Link | |
| Background | This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. provided by RefSeq |
| Synonyms | BP; HP2ALPHA2; HPA1S |
| Reference Data | |
| Protein Categories | Enzyme: Peptidases, Secreated Proteins |
| Protein Families | Druggable Genome, Protease, Secreted Protein, Transmembrane |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI4H5" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF501699 | Carrier-free (BSA/glycerol-free) HP mouse monoclonal antibody, clone OTI4H5 (formerly 4H5) | 100 ug |
$620.00
|
|
| TA501699 | Anti-HP mouse monoclonal antibody, clone OTI4H5 (formerly 4H5) | 100 ul |
$447.00
|
|
| TA501699AM | HP mouse monoclonal antibody, clone 4H5, Biotinylated | 100 ul |
$509.00
|
|
| TA501699BM | HP mouse monoclonal antibody, clone 4H5, HRP conjugated | 100 ul |
$509.00
|
|
Citations
IL-6 induces haptoglobin expression through activating STAT3 in human head and neck cancer
Li, Lee, Hsu et al
J. Oral Pathol. Med. (2019) 49 (1), 49-54 DOI: 10.1111/jop.12958
Li, Lee, Hsu et al
J. Oral Pathol. Med. (2019) 49 (1), 49-54 DOI: 10.1111/jop.12958
AI Summary: OriGene’s anti-Hp antibody was used in this study to detect haptoglobin expression by Western blotting, enabling the authors to assess how IL-6 and STAT3 signaling regulate haptoglobin levels in head and neck cancer cells.
Snippet: After blotting with 2% skim milk for three times, the membrane was immunoreacted with specific primary antibodies, including anti-Hp (1:3000, OriGene Technologies, Maryland, USA), Actin (1:5000;GeneTex, Irvine, CA, USA), STAT3 (1:3000;Cell Signaling Page 14. Accepted;- After blotting with 2% skim milk for three times, the membrane was immunoreacted with specific primary antibodies, including anti-Hp (1:3000, OriGene Technologies, Maryland, USA), Actin (1:5000;Cell Signaling Page 14
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