Amyloid Precursor Protein (APP) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI2B10]
SKU
TA500973BM
APP (Amyloid beta precursor protein) mouse monoclonal antibody, clone OTI2B10 (formerly 2B10), HRP conjugated
$509.00
2 Weeks*
Specifications
| Product Data | |
| Clone Name | OTI2B10 |
|---|---|
| Application | IF, WB |
| Recommended Dilution | WB 1:2000, IF 1:50 |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human APP (NP_000475) produced in HEK293T cell. |
| Buffer | PBS (pH 7.3) containing 1% BSA and 50% glycerol |
| Concentration | 0.5 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | HRP |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 87.0 kDa |
| Gene Name | amyloid beta precursor protein |
| Database Link | |
| Background | This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. |
| Synonyms | AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2 |
| Reference Data | |
| Protein Categories | Chemokines, Growth Factors, Intracellular Proteins, Membrane Proteins, Nervous system: Neurodegenerative diseases, Secreated Proteins |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Alzheimer's disease |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI2B10" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF500973 | Carrier-free (BSA/glycerol-free) APP mouse monoclonal antibody, clone OTI2B10 (formerly 2B10) | 100 ug |
$620.00
|
|
| TA500973 | APP (Amyloid beta precursor protein) mouse monoclonal antibody, clone OTI2B10 (formerly 2B10) | 100 ul |
$447.00
|
|
| TA500973AM | APP (Amyloid beta precursor protein) mouse monoclonal antibody, clone OTI2B10 (formerly 2B10), Biotinylated | 100 ul |
$509.00
|
|
| TA500973S | APP (Amyloid beta precursor protein) mouse monoclonal antibody, clone OTI2B10 (formerly 2B10) | 30 ul |
$200.00
|
|
Citations
Thioredoxin-1 Promotes Mitochondrial Biogenesis Through Regulating AMPK/Sirt1/PGC1α Pathway in Alzheimer's Disease
Jia, Yin, Zhang et al
ASN Neuro (2023) 15, 17590914231159226 DOI: 10.1177/17590914231159226
Jia, Yin, Zhang et al
ASN Neuro (2023) 15, 17590914231159226 DOI: 10.1177/17590914231159226
Cited by 32
AI Summary: OriGene's Aβ mouse monoclonal antibody (TA500973S) was used in this study to detect β-amyloid, helping to assess amyloid deposition and related pathological changes in Alzheimer's disease models.
Snippet: Abcam (Shanghai, China). Caspase-3 rabbit monoclonal antibody (D3R6Y) was obtained from Cell Signaling Technology, Inc. (Danvers, MA, USA). Aβ mouse monoclonal antibody (TA500973S) was obtained from Origene (Rockville, MD, USA). Active Oxygen Detection Kit (S0033S), Annexin V-mCherry Apoptosis Detection Kit (C1070 M), Mito-Tracker Red CMXRos (C1035), and pCMV-Mito-AT1.03 (D2606) were obtained f
Showing 1-1 of 1 papers.
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