CD2AP Rabbit Polyclonal Antibody

SKU TA351042

Rabbit Polyclonal Anti-CD2AP Antibody

Product Data

• Application: IHC, WB
• Recommended Dilution: WB: 1000-5000; WB positive control: A431 and Raji cells; IHC: 100-300; Positive control: Human Lymphoma; Predicted cell location: Cytoplasm
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human CD2AP
• Buffer: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 71 kDa
• Gene Name: CD2-associated protein
• Database Link:
  NP_036252
  Q9Y5K6
• Background: This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.
• Synonyms: CMS

Reference Data

• Protein Families: Druggable Genome