DAB2 Rabbit Polyclonal Antibody
Rabbit Polyclonal Anti-DAB2 Antibody
Product Datasheet for 'TA349863'
|Recommend Dilution||ELISA: 2000-5000, WB: 500-2000, IHC: 50-200|
|Reactivity||Human, Mouse, Rat|
|Immunogen||Fusion protein of human DAB2|
|Formulation||pH7.4 PBS, 0.05% NaN3, 40% Glyceroln|
|Purification||Antigen affinity purification|
|Predicted Protein Size||82 kDa|
|Gene Name||DAB2, clathrin adaptor protein|
|Background||This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.|
|Protein Families||Druggable Genome|
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