DAB2 rabbit Polyclonal Antibody

CAT#: TA349863

Rabbit Polyclonal Anti-DAB2 Antibody


 Product Datasheet for 'TA349863'

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USD 335.00


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Size
    • 100 ul

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Specifications

Product Data
Clone Name Polyclonal
Applications WB, IHC
Recommend Dilution ELISA: 2000-5000, WB: 500-2000, IHC: 50-200
Reactivity H,M,R
Host rabbit
Clonality Polyclonal
Immunogen Fusion protein of human DAB2
Isotype IgG
Formulation pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
Concentration 1.4 mg/ml
Purification Antigen affinity purification
Predicted Protein Size 82 kDa
Gene Name DAB2, clathrin adaptor protein
Background This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms DOC-2|DOC2
Reference Data
Protein Families Druggable Genome
Protein Pathways Endocytosis
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.