LOX Rabbit Polyclonal Antibody

SKU TA337077

Rabbit Polyclonal LOX Antibody

Product Data

• Application: ICC/IF, IHC, IP, WB
• Recommended Dilution: Immunohistochemistry, Knockout Validated, Immunocytochemistry/ Immunofluorescence: 1:10-1:500, Immunoprecipitation: 1:10-1:500, Western Blot: 1:100-1:2000, Immunohistochemistry-Paraffin: 1:10-1:500, Immunohistochemistry-Frozen
• Reactivity: Bovine, Human, Mouse, Primate, Rat
• Antibody Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Within the range of amino acids 305-338 of human LOX protein were used as the immunogen.
• Buffer: Crude whole Rabbit sera with 50% Glycerol, 0.025% Sodium Azide
• Concentration: lot specific
• Purification: Whole antisera
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: lysyl oxidase
• Database Link:
  NP_002308
  P28300
• Background: LOX (lysyl oxidase) is a copper-dependent amine oxidase enzyme responsible for post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. LOX is synthesized as an inactive 50 kD proenzyme that is N-glycosylated in ER/Golgi complex and then secreted into extracellular environment, where it is processed by pro-collagen C-proteinases (mammalian Tolloids and BMP-1) into an active enzyme (28-32 kD) and an 18 kD propeptide (LOX-PP) which can be N-glycosylated intracellularly into a ~35 kD form. LOX activity is critical in maintaining the tensile as well as elastic features of the connective tissues of skeletal, pulmonary and cardiovascular systems. LOX deficiency leads to intra-gestational lethality in LOX-/- mice wherein the pups exhibits aortic aneurysms/tortuosity/rupture. LOX expression is highly regulated during normal development; and, its aberrant expression or activity has been documented in a range of diseases predominantly associated with the ECM such as Cutis laxa or OHS (occipital horn syndrome), Menkes' syndrome, myocardial ischaemia/heart failure, atherosclerosis, scleroderma, liver cirrhosis, Pseudoexfoliation syndrome and glaucoma, Alzheimer's/non-Alzheimer's dementia, Wilson's disease, primary biliary cirrhosis as well as in many type of cancers, wherein LOX implicates in promoting tumor cell invasion and metastasis.
• Synonyms: MGC105112

Reference Data

• Protein Families: Druggable Genome, Secreted Protein