LOX (NM_002317) Human Recombinant Protein
$867.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 46.8 kDa |
| Concentration | >0.1 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Bioactivity | Enzyme activity (PMID: 25924936) In vivo treatment (PMID: 26017313) Cell treatment (PMID: 26077591) Binding assay (PMID: 26601954) In vivo treatment (PMID: 28445728) |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_002308 |
| Locus ID | 4015 |
| UniProt ID | P28300 |
| Cytogenetics | 5q23.1 |
| RefSeq Size | 1946 |
| RefSeq ORF | 1251 |
| Synonyms | AAT10 |
| Summary | This gene encodes a member of the lysyl oxidase family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a regulatory propeptide and the mature enzyme. The copper-dependent amine oxidase activity of this enzyme functions in the crosslinking of collagens and elastin, while the propeptide may play a role in tumor suppression. In addition, defects in this gene have been linked with predisposition to thoracic aortic aneurysms and dissections. provided by RefSeq, Jul 2016 |
| Protein Categories | Cardiovascular diseases, Chemokines, Growth Factors, Intracellular Proteins, Secreated Proteins |
| Protein Families | Druggable Genome, Secreted Protein |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "LOX" proteins (5)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH313323 | LOX MS Standard C13 and N15-labeled recombinant protein (NP_002308) | 10 ug |
$3,360.00
|
|
| LC400843 | Lyophilized LOX HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY400843 | Transient overexpression lysate of lysyl oxidase (LOX) (as WB positive control) | 100 ug |
$436.00
|
|
| TP700002 | Recombinant protein of N-terminal propeptide (LOXPP) of human lysyl oxidase (LOX), with C-terminal DDK/His tag, expressed in human cells | 20 ug |
$900.00
|
|
| TP790154 | Purified recombinant protein of Human lysyl oxidase (LOX), with C-terminal DDK tag, secretory expressed in CHO cells, 20ug | 20 ug |
$900.00
|
|
Citations
Lysyl oxidase drives ccRCC progression by coordinating HIF-2α transcription program with tumor microenvironment
Ulukan, Saatci, Madrigal et al
bioRxiv (2026)
Ulukan, Saatci, Madrigal et al
bioRxiv (2026)
AI Summary: OriGene’s recombinant human LOX protein (Cat. no. TP313323) was used to assess LOX-mediated oxidative modification of HIF-2α, helping to demonstrate LOX’s role in stabilizing HIF-2α and promoting ccRCC progression.
Snippet: For the detection of LOX-mediated oxidative modifications, protein carbonylation was assessed 570 using biotin hydrazide labeling. …Bead-bound HIF-2α was incubated with recombinant human LOX (Origene, Cat. 573 no.TP313323) in oxidation buffer (50 mM HEPES and 10 mM CaCl2, pH 8.0) at 37 °C for 45 min
Lysyl Oxidase Reduces Neutrophil Extravasation in Response to P. aeruginosa in an Infection‐on‐a‐Chip Model
Calo, Patil, Fouts et al
Advanced NanoBiomed Research (2026)
Calo, Patil, Fouts et al
Advanced NanoBiomed Research (2026)
Cited by 1
Extracellular Matrix Regulation of the Neutrophil Inflammatory Response
Calo
Thesis (2025)
Calo
Thesis (2025)
Snippet: supplemented with 10% fetal bovine serum (FB12999102, Fisher Scientific, Pittsburgh, PA) and either 150 ng mL-1 of human recombinant lysyl oxidase (LOX, TP313323, OriGene, Rockville, MD) or no LOX for 5 days with daily media changes. LOX stock solutions were stored at 15 µg mL-1 in 25mM Tris HCl (50-213-710, Fisher Scientific, Mt. Prospect, IL) 100 mM glycine (G
A highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer
Cetin, Saatci, Rezaeian et al
Cell Chem Biol (2024)
Cetin, Saatci, Rezaeian et al
Cell Chem Biol (2024)
Cited by 33
Regulation of Atp7a RNA contributes to differentiation-dependent Cu redistribution in skeletal muscle cells
Whitlow, Zhang, Ferguson et al
Metallomics (2023) 15 (7) DOI: 10.1093/mtomcs/mfad042
Whitlow, Zhang, Ferguson et al
Metallomics (2023) 15 (7) DOI: 10.1093/mtomcs/mfad042
Cited by 18
AI Summary: OriGene products, specifically the Atp7a (NM_009726) qPCR primer pair (catalog #MP207396) and Atp7a shRNA plasmid (catalog #TR512995), were used in this study to measure Atp7a mRNA levels and to knock down Atp7a expression, respectively, thereby enabling the authors to investigate the regulation and functional role of ATP7A in copper-dependent skeletal muscle differentiation.
Snippet: nases including MEK, ULK1, CK2, and PDK1.4–7 These kinases are needed for fundamental processes like cell proliferation, survival, and autophagy and are important for both normal cell growth and tumorigenesis. Cu can also promote the activity of E2D ubiquitin ligases and influence ubiquitylation and proteostasis.8 Conversely, Cu binding can inhibit enzyme activity in the case of the phosphodiest
Accurate quantification of lysyl oxidase concentration in human tissue
Yao, Perryman, Zahoor et al
bioRxiv (2023)
Yao, Perryman, Zahoor et al
bioRxiv (2023)
Showing 1-6 of 18 papers.
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