PRMT6 Rabbit Polyclonal Antibody

SKU TA336434

Rabbit Polyclonal PRMT6 Antibody

Product Data

• Application: WB
• Recommended Dilution: Western Blot: 1:500-1:1000, In vitro assay
• Reactivity: Human, Mouse
• Antibody Host: Rabbit
• Clonality: Polyclonal
• Immunogen: This antibody was developed a synthetic peptide corresponding to amino acids 23-43 (CEEDGAEREAALERPRRTKRER) of human PRMT6.
• Buffer: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Whole antisera
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: protein arginine methyltransferase 6
• Database Link:
  NP_060607
  Q96LA8
• Background: Protein arginine methylation is an important posttranslational modification in eukaryotic cells, which has been implicated in RNA processing and trafficking, receptor-mediated signaling, and transcription. PRMT6 was identified by searching the human genome for protein arginine N-methyltransferase (PRMT) family members. PRMT6 cDNA codes for a protein of approximate molecular weight of 42 kDa consisting of a catalytic core sequence common to other PRMT enzymes. PRMT6 demonstrates type I PRMT activity, capable of forming both >NG-monomethylarginine and asymmetric >NG,NG-dimethylarginine derivatives on the recombinant glycine- and arginine-rich substrates. A comparison of substrate specificity reveals that PRMT6 is functionally distinct from two previously characterized type I enzymes, PRMT1 and PRMT4. In addition to methylating substrate proteins, PRMT6 displays automethylation activit. GFP-fusion protein expression in the transfected cell lines suggest that PRMT6 localizes in the nucleus.
• Synonyms: HRMT1L6

Reference Data

• Protein Families: Druggable Genome