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CYLD Rabbit Polyclonal Antibody

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SKU
TA336362
Rabbit Polyclonal CYLD Antibody
Size:
100 ug
Conjugation:
Unconjugated
  $585.00
5 Days*
Bulk/Customize

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View other "CYLD or NM_001042355" antibodies

Specifications
Specifications
Product Data
Application ICC/IF, Simple Western, WB
Recommended Dilution Immunocytochemistry/ Immunofluorescence: 5-10 ug/ml, Western Blot: 2-4 ug/ml, Simple Western: 1:50
Reactivity Human
Antibody Host Rabbit
Clonality Polyclonal
Immunogen A synthetic peptide (DKQTQKLLKVPKGS) corresponding to amino acids 32-45 of human CYLD was used as immunogen (NP_001035877).
Buffer PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Protein G purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Gene Name CYLD lysine 63 deubiquitinase
Database Link
Background CYLD is a 956 aa, cytoplasmic, deubiquitinating enzyme belonging to the ubiquitin carboxy-terminal hydrolases (UCH) family of proteins with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains, a proline rich region, a SH3 binding domain and a sequence homology to catalytic domain of UCH. CYLD is identified as a tumor suppressor protein affecting the JNK signaling pathway. CYLD is a negative regulator of TRAF2 and NF-kappa-B signaling pathway and is also known to have receptor-dependent role in regulating the I-kappa-B kinase pathway. It also has a deubiquitinating activity that is directed towards non-Lys-48-linked polyubiquitin chains and TRAP1 is a novel substrate for deubiquitination. Mutated CYLD is known to be associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome.
Synonyms BRSS; CDMT; CYLD1; CYLDI; EAC; MFT; MFT1; SBS; TEM; USPL2
Reference Data
Protein Categories Enzyme: Peptidases, Intracellular Proteins, Nervous system: Neurodegenerative diseases
Protein Families Druggable Genome
Protein Pathways RIG-I-like receptor signaling pathway
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.