SETDB1 Rabbit Polyclonal Antibody

CAT#: TA332979

Rabbit anti-SETDB1 Polyclonal Antibody

Product Images

Western blot analysis of extracts of various cell lines, using SETDB1 antibody.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB 1:500 - 1:2000
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human SETDB1
• Formulation: Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: SET domain bifurcated 1
• Database Link:
  NP_036564
  Entrez Gene 84505 MouseEntrez Gene 689883 RatEntrez Gene 9869 Human
  UniProt ID Q15047
• Background: This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.
• Synonyms: ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Lysine degradation