p63 (TP63) Rabbit Polyclonal Antibody [Clone ID: Poly6190]

CAT#: TA327976

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Rabbit Polyclonal anti-p63 (?N) Antibody


Product Datasheet for 'TA327976'


 Cited in 1 publication.

USD 375.00


Availability*
2 Weeks

Size
    • 200 ul


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Specifications

Product Data
Clone Name Poly6190
Applications IF, WB
Recommended Dilution WB, IF, IHC
Reactivity Human (recognizes ΔN-isoforms)
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Modified peptide
Formulation This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 50% glycerol.
Purification The antibody was purified by antigen-affinity chromatography.
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 52 kD, 45 kD
Gene Name tumor protein p63
Background p63 (ΔN) is a member of the p53 family. This protein has multiple isoforms TA p63-α, -β, γ, ΔN p63-α, -β, and -γ. The molecular weights of the p63 isoforms α=66 kD, β=52 kD, and γ=45 kD. This nuclear protein is essential for limb formation, epidermal morphogenesis, and epithelial stem cell regeneration. ΔN isoforms are antagonistic to p53; TA isoforms can transactivate p53 targets. The p63 ΔN isoforms repress TA isoforms; mutant p53 abrogates p63 transactivation. This protein interacts with p53, p73, and the various TA- and ΔN isoforms. The Poly6190 antibody recognizes human p63 ΔN isoforms and has been shown to be useful for Western blotting.
Synonyms AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; RHS; SHFM4; TP53CP; TP53L; TP73L; p40; p51; p53CP; p63; p73H; p73L
Reference Data
Protein Families Druggable Genome, Transcription Factors

Citations (1)

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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