p63 (TP63) Rabbit Polyclonal Antibody [Clone ID: Poly6190]
Specifications
| Product Data | |
| Clone Name | Poly6190 |
|---|---|
| Application | IF, WB |
| Recommended Dilution | WB, IF, IHC |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Modified peptide |
| Buffer | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 50% glycerol. |
| Purification | The antibody was purified by antigen-affinity chromatography. |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 52 kD, 45 kD |
| Gene Name | tumor protein p63 |
| Database Link | |
| Background | p63 (ΔN) is a member of the p53 family. This protein has multiple isoforms TA p63-α, -β, γ, ΔN p63-α, -β, and -γ. The molecular weights of the p63 isoforms α=66 kD, β=52 kD, and γ=45 kD. This nuclear protein is essential for limb formation, epidermal morphogenesis, and epithelial stem cell regeneration. ΔN isoforms are antagonistic to p53; TA isoforms can transactivate p53 targets. The p63 ΔN isoforms repress TA isoforms; mutant p53 abrogates p63 transactivation. This protein interacts with p53, p73, and the various TA- and ΔN isoforms. The Poly6190 antibody recognizes human p63 ΔN isoforms and has been shown to be useful for Western blotting. |
| Synonyms | AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; p40; p51; p53CP; p63; p73H; p73L; RHS; SHFM4 |
| Reference Data | |
| Protein Categories | Intracellular Proteins, Transciption Factors |
| Protein Families | Druggable Genome, Transcription Factors |
Reviews
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Citations
Interleukin-17A mediates tobacco smoke-induced lung cancer epithelial-mesenchymal transition through transcriptional regulation of ΔNp63α on miR-19
Xie, Zhu, Huang et al
Cell Biol Toxicol (2021)
Xie, Zhu, Huang et al
Cell Biol Toxicol (2021)
Cited by 12
Sulforaphane Inhibits the Acquisition of Tobacco Smoke-Induced Lung Cancer Stem Cell-Like Properties via the IL-6/ΔNp63α/Notch Axis
Xie, Zhu, Jiang et al
Theranostics (2019) 9 (16), 4827-4840 DOI: 10.7150/thno.33812
Xie, Zhu, Jiang et al
Theranostics (2019) 9 (16), 4827-4840 DOI: 10.7150/thno.33812
AI Summary: In this study, the OriGene ΔNp63α antibody (TA327976) was used to detect ΔNp63α protein expression by western blotting, enabling the authors to investigate its role in tobacco smoke-induced lung cancer stem cell-like properties.
Snippet: The membranes were blocked with 5 % nonfat dry milk at 25 °C for 1 h on a rotary shaker and incubated overnight at 4 °C with the following primary antibodies: ΔNp63α (TA327976;OriGene Technologies, Rockville, MD, USA);CD133 (18470-1-AP), ALDH1A1 (15910;
Showing 1-2 of 2 papers.
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