SOX4 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | FC, IF, IHC, WB |
|---|---|
| Recommended Dilution | WB:1/1000, IHC-P:1/50-200, IF:1/10-50, FC:1/10-50 |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | This SOX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-114 amino acids from the N-terminal region of human SOX4. |
| Specificity | This SOX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-114 amino acids from the N-terminal region of human SOX4. |
| Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| Concentration | lot specific |
| Purification | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Blue Ice |
| Predicted Protein Size | 47.3 kDa |
| Gene Name | SRY-box 4 |
| Database Link | |
| Background | SOX4 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein. |
| Synonyms | EVI16 |
| Reference Data | |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Stem cell relevant signaling - TGFb/BMP signaling pathway, Transcription Factors |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
miR-335-laden B Cell-Derived Extracellular Vesicles Promote SOX4-Dependent Apoptosis in Human Multiple Myeloma Cells
Lombardi, Almanza, Kowal et al
J Pers Med (2021) 11 (12) DOI: 10.3390/jpm11121240
Lombardi, Almanza, Kowal et al
J Pers Med (2021) 11 (12) DOI: 10.3390/jpm11121240
Cited by 10
AI Summary: In this study, OriGene’s SOX4 (Cat# RC218364) and HIF1A (Cat# RC221345) expression plasmids were used to investigate the regulatory effects of miR-335 on SOX4 and HIF1A in multiple myeloma cell models.
Showing 1-1 of 1 papers.
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