SPIN2B Rabbit Polyclonal Antibody

SKU TA323478

Anti-SPIN2B Rabbit Polyclonal Antibody

Product Data

• Application: IHC, WB
• Recommended Dilution: WB: 500-2000; WB positive control: Hela cell lysate; IHC: 50-200; Positive control: Human liver cancer; Predicted cell location: Nucleus and Cytoplasm
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Full length fusion protein
• Buffer: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 29 kDa
• Gene Name: spindlin family member 2B
• Database Link:
  NP_001006682
  Q9BPZ2
• Background: Human SPIN2 expressed by 2 IL3-dependent murine myeloid cell lines was moderately antiapoptotic following IL3 removal; but it was unable to block apoptosis induced by the chemotherapy agent doxorubicin. On the contrary; SPIN2-expressing cells were more sensitive to doxorubicin-mediated cell death. Also; SPIN2 did not combat the proapoptotic effects of Fas ligand stimulation in the Jurkat human T-cell line. Deletion of the C-terminal amino acids of SPIN2 diminished its antiapoptotic activity. In the murine myeloid cells; SPIN2 overexpression increased the cell number doubling times and slowed their rate of growth. There was also an increased percentage of cells in G2/M; which was more pronounced following IL3 withdrawal.
• Synonyms: dJ323P24.2; SPIN-2; SPIN-2B; SPIN2_duplicate; TDRD26

Reference Data