AADAC Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC, WB |
|---|---|
| Recommended Dilution | WB: 500-2000 WB positive control: Human fetal liver and liver cancer tissue IHC: 25-100 Positive control: Human colon cancer Predicted cell location: Cytoplasm |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Fusion protein corresponding to C terminal 250 amino acids of human arylacetamide deacetylase |
| Buffer | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 46 kDa |
| Gene Name | arylacetamide deacetylase |
| Database Link | |
| Background | Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase; which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens. Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also flutamide; which is an antiandrogen drug used for the treatment of prostate cancer that occasionally causes severe hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty acids derived from hydrolysis of newly formed triglyceride stores. |
| Synonyms | CES5A1; DAC |
| Reference Data | |
| Protein Categories | Intracellular Proteins |
| Protein Families | Druggable Genome, Transmembrane |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis
Toyohara, Roudnicky, Florido et al
Cell Stem Cell (2020) 27 (1), 147-157.e7 DOI: 10.1016/j.stem.2020.04.018
Toyohara, Roudnicky, Florido et al
Cell Stem Cell (2020) 27 (1), 147-157.e7 DOI: 10.1016/j.stem.2020.04.018
Cited by 36
AI Summary: In this study, the OriGene AADAC antibody (TA323312) was used to detect and analyze the expression of arylacetamide deacetylase (AADAC) in vascular smooth muscle cells, helping to demonstrate its protective role against atherosclerosis.
Snippet: Skip to article;VE-Cadherin R&D AF938 RRID:AB_355726 vWF Dako A0082 RRID:AB_2315602 aSMA for ICC/IF Abcam ab7817 RRID:AB_262054 Calponin Abcam ab46794 RRID:AB_2291941 AADAC Origene TA323312 bActin Santa Cruz sc-47778 RRID:AB_2714189 PCNA Abcam Ab29 RRID:AB_303394 Cleaved Caspase 3 Cell Signaling Technology 9664 RRID:AB_2070042 GFP Abcam ab6556 RRID:AB_305564
Showing 1-1 of 1 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
Related Products
- Price:
- Actual Price:
Welcome to OriGene AI!
I'm your AI-powered guide to everything OriGene.
Ask me anything:
- Product specs
- Ordering help
- Technical questions
- How to find exactly what your experiment needs
Prefer a live agent? Connect with us by clicking the green chat icon, as seen in the image below or email our team at custsupport@origene.com.
