DTX2 Rabbit Polyclonal Antibody

SKU TA323238

Anti-DTX2 Rabbit Polyclonal Antibody

Product Data

• Application: IHC
• Recommended Dilution: IHC: 50-100; Positive control: Human brain; Predicted cell location: Cytoplasm and Nucleus
• Reactivity: Human, Mouse
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to C terminal 300 amino acids of human deltex homolog 2 (Drosophila)
• Buffer: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Gene Name: deltex 2, E3 ubiquitin ligase
• Database Link:
  NP_065943
  Q86UW9
• Background: DTX2 functions as an E3 ubiquitin ligase. Regulator of Notch signaling; a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch; depending on the developmental and cell context. Mediates the antineural activity of Notch; possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as an ubiquitin ligase protein in vitro; suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.
• Synonyms: RNF58

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Notch signaling pathway