DUSP6 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC |
|---|---|
| Recommended Dilution | IHC: 50-200 Positive control: Human colon cancer Predicted cell location: Cytoplasm |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Fusion protein corresponding to a region derived from 206-381 amino acids of human dual specificity phosphatase 6 |
| Buffer | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | dual specificity phosphatase 6 |
| Database Link | |
| Background | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK; SAPK/JNK; p38); which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases; different tissue distribution and subcellular localization; and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2; is expressed in a variety of tissues with the highest levels in heart and pancreas; and unlike most other members of this family; is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.? |
| Synonyms | HH19; MKP3; PYST1 |
| Reference Data | |
| Protein Categories | Endocrine and metabolic diseases, Growth Factors, Intracellular Proteins |
| Protein Families | Druggable Genome, Phosphatase |
| Protein Pathways | MAPK signaling pathway |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Dusp6 deficiency attenuates neutrophil-mediated cardiac damage in the acute inflammatory phase of myocardial infarction
Zhou, Zhang, Wu et al
Nat Commun (2022) 13 (1), 6672 DOI: 10.1038/s41467-022-33631-z
Zhou, Zhang, Wu et al
Nat Commun (2022) 13 (1), 6672 DOI: 10.1038/s41467-022-33631-z
Cited by 46
AI Summary: OriGene’s DUSP6 antibody (TA323084) was used for immunohistochemistry to detect and localize DUSP6-expressing cells in infarcted heart tissue, helping to confirm the presence and dynamics of DUSP6 after myocardial infarction in this study.
Snippet: DUSP6 signal was largely reduced in Dusp6-deficient cells (Supplementary Fig. 5a, b), confirming the specificity of this antibody. Furthermore, by immunohistochemistry with another DUSP6 antibody (Origene, TA323084), we found a large number of DUSP6-labeled cells in infarcted LV tissues at 1, 3, and 7 days after MI, but minimal or no DUSP6 expression in the sham-operated hearts (Fig. 3c). We n;- Furthermore, by immunohistochemistry with another DUSP6 antibody (Origene, TA323084), we found a large number of DUSP6-labeled cells in infarcted LV tissues at 1, 3
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