DUSP6 (NM_001946) Human Recombinant Protein
SKU
TP306765
Recombinant protein of human dual specificity phosphatase 6 (DUSP6), transcript variant 1, 20 µg
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 42.1 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_001937 |
| Locus ID | 1848 |
| UniProt ID | Q16828 |
| Cytogenetics | 12q21.33 |
| RefSeq Size | 3395 |
| RefSeq ORF | 1143 |
| Synonyms | HH19; MKP3; PYST1 |
| Summary | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. provided by RefSeq, Jan 2014 |
| Protein Categories | Endocrine and metabolic diseases, Growth Factors, Intracellular Proteins |
| Protein Families | Druggable Genome, Phosphatase |
| Protein Pathways | MAPK signaling pathway |
Reviews
Documents
| FAQs |
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Resources
| Recombinant Protein Resources |
Other "DUSP6" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH306765 | DUSP6 MS Standard C13 and N15-labeled recombinant protein (NP_001937) | 10 ug |
$3,360.00
|
|
| LC419629 | DUSP6 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY419629 | Transient overexpression lysate of dual specificity phosphatase 6 (DUSP6), transcript variant 1 | 100 ug |
$436.00
|
|
OriGene AI
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.