PDGF AA (PDGFA) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IHC |
|---|---|
| Recommended Dilution | IHC: 50-200 Positive control: Human ovarian cancer Predicted cell location: Cytoplasm |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | Synthetic peptide corresponding to a region derived from 101-114 amino acids of Human platelet-derived growth factor alpha polypeptide |
| Buffer | PBS pH7.3, 0.05% NaN3, 50% glycerol |
| Concentration | lot specific |
| Purification | Antigen affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | platelet derived growth factor subunit A |
| Database Link | |
| Background | The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide; where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes; alveolar smooth muscle cells; and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene. |
| Synonyms | PDGF-A; PDGF1 |
| Reference Data | |
| Protein Categories | Cancer: Brain and CNS, Cancer: Lung, Growth Factors, Intracellular Proteins, Secreated Proteins |
| Protein Families | Druggable Genome |
| Protein Pathways | Cytokine-cytokine receptor interaction, Focal adhesion, Gap junction, Glioma, MAPK signaling pathway, Melanoma, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Citations
Force dependent effects of chronic overuse on fibrosis-related genes and proteins in skeletal muscles
Hilliard, Amin, Popoff et al
Connect Tissue Res (2020)
Hilliard, Amin, Popoff et al
Connect Tissue Res (2020)
Cited by 15
AI Summary: OriGene's anti-FGF2 antibody (TA322986) was used to detect FGF2 protein levels in rat muscle tissues, enabling the study to assess fibrosis-related changes following chronic muscle overuse.
Snippet: TA322986, Origene, Rockville, MD) at a dilution of 1:100 in phosphate-buffered saline (PBS), or an anti-collagen type 1 monoclonal antibody (clone COL1, Catalog No. C2456, Sigma, St Louis MO) at a 1:500 dilution in PBS containing 10% goat serum
Showing 1-1 of 1 papers.
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