DNMT3L Rabbit Polyclonal Antibody
Anti-DNMT3L Rabbit Polyclonal Antibody
Product Datasheet for 'TA321825'
|Recommend Dilution||ELISA: 1:1000-2000, IHC: 1:10-50|
|Reactivity||Human, Mouse, Rat|
|Immunogen||Fusion protein corresponding to C terminal 300 amino acids of human DNA (cytosine-5-)-methyltransferase 3-like|
|Formulation||PBS pH7.3, 0.05% NaN3, 50% glycerol|
|Purification||Antigen affinity purification|
|Gene Name||DNA (cytosine-5-)-methyltransferase 3-like|
|Background||CpG methylation is an epigenetic modification that is important for embryonic development; imprinting; and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases; but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However; it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.|
|Protein Families||Druggable Genome, Transcription Factors|
|Protein Pathways||Cysteine and methionine metabolism, Metabolic pathways|
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.