DNMT3L Rabbit Polyclonal Antibody

CAT#: TA321825

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Anti-DNMT3L Rabbit Polyclonal Antibody



USD 345.00


Availability*
4 Weeks

Size
    • 100 ul


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Specifications

Product Data
Applications IHC
Recommended Dilution ELISA: 1:1000-2000, IHC: 1:10-50
Reactivity Human, Mouse, Rat
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Fusion protein corresponding to C terminal 300 amino acids of human DNA (cytosine-5-)-methyltransferase 3-like
Formulation PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration 0.5mg/ml
Purification Antigen affinity purification
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name DNA (cytosine-5-)-methyltransferase 3-like
Background CpG methylation is an epigenetic modification that is important for embryonic development; imprinting; and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases; but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However; it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms MGC1090
Reference Data
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Cysteine and methionine metabolism, Metabolic pathways
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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