DNMT3L Rabbit Polyclonal Antibody

CAT#: TA321825

Anti-DNMT3L Rabbit Polyclonal Antibody

Product images

Predicted cell location: Cytoplasm. Positive control: Human thyroid cancer tissue. Recommended dilution: 1/10-50 The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using DNMT3L antibody at dilution 1/15, on the right is treated with the fusion protein. (Original magnification: x200)

Specifications

Product Data

• Applications: IHC
• Recommend Dilution: ELISA: 1:1000-2000, IHC: 1:10-50
• Reactivity: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to C terminal 300 amino acids of human DNA (cytosine-5-)-methyltransferase 3-like
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: 0.5mg/ml
• Purification: Antigen affinity purification
• Gene Name: DNA (cytosine-5-)-methyltransferase 3-like
• Database Link:
  NP_037501
  Entrez Gene 54427 MouseEntrez Gene 309680 RatEntrez Gene 29947 Human
• Background: CpG methylation is an epigenetic modification that is important for embryonic development; imprinting; and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases; but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However; it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
• Synonyms: MGC1090

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Cysteine and methionine metabolism, Metabolic pathways