DUT Rabbit Polyclonal Antibody

SKU TA321412

Anti-DUT Rabbit Polyclonal Antibody

Product Data

• Application: IHC
• Recommended Dilution: IHC: 25-100; Positive control: Human gasrtic cancer; Predicted cell location: Cytoplasm and Nucleus
• Reactivity: Human, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region derived from 132-244 amino acids of Human Deoxyuridine triphosphatase
• Buffer: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 27 kDa
• Gene Name: deoxyuridine triphosphatase
• Database Link:
  NP_001939
  P33316
• Background: This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous; homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication; and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA; which induces extensive excision repair mediated by uracil glycosylase. This repair process; resulting in the removal and reincorporation of dUTP; is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.
• Synonyms: dUTPase

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Metabolic pathways, Pyrimidine metabolism