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PCBP2 Rabbit Polyclonal Antibody

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SKU
TA308051
Rabbit Polyclonal antibody to PCBP2 (poly(rC) binding protein 2)
Size:
100 ul
Conjugation:
Unconjugated
  $665.00
In Stock*
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View other "PCBP2 or NM_005016" antibodies

Specifications
Specifications
Product Data
Application IF, IHC, WB
Recommended Dilution ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
Reactivity Bovine), Human, Mouse (Predicted: Rat, Pig
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Recombinant fragment corresponding to a region within amino acids 1 and 193 of PCBP2 (Uniprot ID#Q15366)
Buffer 0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Concentration lot specific
Purification Purified by antigen-affinity chromatography.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 38 kDa
Gene Name poly(rC) binding protein 2
Database Link
Background The protein encoded by this gene appears to be multifunctional. Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins. The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding. Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2. This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2). Multiple transcript variants encoding different isoforms have been found for this gene. provided by RefSeq
Synonyms hnRNP-E2; HNRNPE2; HNRPE2
Note Seq homology of immunogen across species: Rat (100%), Pig (100%), Bovine (100%)
Reference Data
Protein Categories Intracellular Proteins
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Documents
Resources

file-alt Citations

Loss of monopolar spindle-binding protein 3B expression promotes colorectal cancer invasiveness by activation of target of rapamycin kinase/autophagy signaling
Sun, Zhang, Li et al
World J Gastroenterol (2024) 30 (26), 3229-3246 DOI: 10.3748/wjg.v30.i26.3229
Cited by 1
AI Summary: In this study, OriGene’s Splink Detection kits (Cat. #SP-9000) were used to facilitate immunohistochemical detection, contributing to the analysis of MOB3B expression in colorectal cancer tissue samples.
Snippet: … Polyvinylidene fluoride (PVDF) membranes were from Millipore (Billerica, MA, United States), and the Splink Detection kits (Cat. #SP-9000) were purchased from OriGene Technologies (Beijing, China). MHY1485 (Cat. #HY-B0795) and rapamycin (Cat. #HY-10219) were obtained from MedChemExpress (Shanghai, China)
FigureFigureFigure
IHC
In-cell NMR suggests that DNA i-motif levels are strongly depleted in living human cells
Víšková, Ištvánková, Ryneš et al
Nat Commun (2024) 15 (1), 1992 DOI: 10.1038/s41467-024-46221-y
Cited by 66
AI Summary: OriGene's rabbit polyclonal anti-PCBP2 antibody (TA308051) was used as a primary antibody in Shift-Western Blot assays to detect PCBP2 protein levels in this study.
Snippet: primary and secondary antibodies used in Shift-Westen-Blot assay TARGET ORIGIN CONJUGATED DILUTION MANUFACTURER CAT. NUMBER Primary antibodies PCBP2 rabbit polyclonal 1:1000 Origene TA308051 hnRNP K mouse monoclonal 1:1000 Abcam ab39975 hnRNP A1 mouse monoclonal 1:1000 Sigma Aldrich R4528 Secondary antibodies rabbit IgG goat HRP 1:10000
FigureFigure
WB
Showing 1-2 of 2 papers.
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