JMJD6 Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IF, IHC, WB |
|---|---|
| Recommended Dilution | WB: 1 - 2 ug/mL, ICC: 2.5 ug/mL, IF: 20 ug/mL |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Polyclonal |
| Immunogen | JMJD6 antibody was raised against a 15 amino acid peptide from near the amino terminus of human JMJD6. |
| Buffer | PBS containing 0.02% sodium azide. |
| Purification | Affinity chromatography purified via peptide column |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Gene Name | arginine demethylase and lysine hydroxylase |
| Database Link | |
| Background | The jumonji domain-containing protein (JMJD) family is defined by the presence of the JmjC domain that is observed in several diverse species. JMJD6 was initially identified as a membrane protein that participates in phagocytosis but recent studies have shown that it has other functions when it is expressed in the cytosol and nucleus. JMJD6 is thought to play important roles in regulation of development and differentiation as knockdown experiments in mice resulted in neonatal lethality with severe defects in the morphology of numerous organs. JMJD6 also can catalyze the lysyl-hydroxylation of U2AF65, a protein involved with RNA splicing, suggesting that some of the functions attributed to JMJD6 may be due to its regulatory activity of RNA splicing. |
| Synonyms | PSR; PTDSR; PTDSR1 |
| Reference Data | |
| Protein Categories | Intracellular Proteins |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS |
Reviews
Documents
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Citations
Demethylase JMJD6 as a New Regulator of Interferon Signaling: Effects of HCV and Ethanol Metabolism
Ganesan, Tikhanovich, Vangimalla et al
Cell Mol Gastroenterol Hepatol (2018) 5 (2), 101-112 DOI: 10.1016/j.jcmgh.2017.10.004
Ganesan, Tikhanovich, Vangimalla et al
Cell Mol Gastroenterol Hepatol (2018) 5 (2), 101-112 DOI: 10.1016/j.jcmgh.2017.10.004
Cited by 28
AI Summary: OriGene products contributed to this paper by providing JMJD6 overexpression plasmids (Cat# RC204307) and JMJD6-specific siRNA (Cat# SR320185), which were used to manipulate JMJD6 levels in hepatocytes to study its role in STAT1 methylation and interferon signaling.
Demethylase JMJD6 as a new regulator of interferon signaling: effects of HCV and ethanol metabolism
Ganesan, IrinaTikhanovich, Vangimalla et al
Cellular and Molecular Gastroenterology and Hepatology (2017)
Ganesan, IrinaTikhanovich, Vangimalla et al
Cellular and Molecular Gastroenterology and Hepatology (2017)
Showing 1-2 of 2 papers.
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