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PROX1 (C-term) Rabbit Polyclonal Antibody

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SKU
DP3516
PROX1 (C-term) rabbit polyclonal antibody, Purified
Size:
200 ug 100 ug
Conjugation:
Unconjugated
  $580.00
2 Weeks*
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View other "PROX1 or NP_002754.2" antibodies

Specifications
Specifications
Product Data
Application IF, IHC, WB
Recommended Dilution Western blot: 1-5 µg/ml.
Immunofluorescence: 1/750-1/1000.
Immunohistochemistry: The antibody works well with paraffin sections. A boiling step is recommended when staining paraffin-embedded tissues.
Reactivity Human, Mouse, Rat
Antibody Host Rabbit
Clonality Polyclonal
Immunogen Highly pure (>95%) recombinant Human, highly conserved C-terminal part of Prox1 (homeo domain and prospero domain) derived from E.coli (Cat.-No DA3565).
Specificity This antibody detects Prox-1 in the nucleus of lymphatic endothelial cells.
Buffer 5mM PBS, pH 7.2 without stabilizer or preservative
State: Purified
State: Lyophilized purified IgG fraction
Reconstitution Method Restore in sterile water to a concentration of 0.1-1.0 mg/ml.
Purification Protein A Chromatography
Conjugation Unconjugated
Storage Store lyophilized at 2-8°C for 6 months or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Shipping Ambient
Gene Name prospero homeobox 1
Database Link
Background Prox-1 is a homeobox gene and acts as a master switch for lymphatic endothelial phenotype. Expression of Prox-1 in blood endothelial cells induces expression of other lymphatic marker genes. Together with Podoplanin, Prox-1 can be used to reliably distinguish lympathic vessels from blood vessels. Prox1 is expressed in CNS, eye, pancreas, liver and heart, and it is one of the most specific and reliable markers for lymphatic endothelial cells.
Synonyms PROX1
Reference Data
Protein Categories Growth Factors, Intracellular Proteins, Transciption Factors
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Documents
Resources

file-alt Citations

Ileitis-associated tertiary lymphoid organs arise at lymphatic valves and impede mesenteric lymph flow in response to tumor necrosis factor
Czepielewski, Erlich, Onufer et al
Immunity (2021) 54 (12), 2795-2811.e9 DOI: 10.1016/j.immuni.2021.10.003
Cited by 79
AI Summary: OriGene’s rabbit anti-mouse PROX1 (C-term) antibody (Cat #: DP3516) was used in this study to identify and analyze lymphatic endothelial cells, aiding in the characterization of tertiary lymphoid organ formation in Crohn's disease models.
Snippet: Rabbit anti-mouse PROX1 (C-term) Origene/Acris Cat #: DP3516;RRID:AB_1006738
Pax6 is essential for lens fiber cell differentiation
Shaham, Smith, Robinson et al
Development (2009) 136 (15), 2567-78 DOI: 10.1242/dev.032888
Cited by 131
AI Summary: OriGene products contributed to this study by providing the Pax6 (OriGene: sc-81395) and Sox2 (OriGene: sc-17320) antibodies, which were used for immunohistochemistry and protein detection to assess the roles of these transcription factors in lens fiber cell differentiation.
Showing 1-2 of 2 papers.
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