PROX1 (C-term) Rabbit Polyclonal Antibody
Specifications
| Product Data | |
| Application | IF, IHC, WB |
|---|---|
| Recommended Dilution | Western blotting: 1-5 µg/ml. Immunohistochemistry/Immunofluorescence: 1/750-1/1,000. |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Highly pure (> 95%) recombinant Human C-terminal part of the Homeobox Transcription Factor Prox-1 (Ala547-Glu737). |
| Specificity | This antibody detect Prox-1 in the nucleus of lymphatic endothelial cells by immunostaining. |
| Buffer | 5 mM PBS pH 7.2 without preservatives State: Purified State: Lyophilized purified Ig fraction |
| Reconstitution Method | Restore in sterile water to a concentration of 0.1-1.0 mg/ml. |
| Purification | Protein A Chromatography |
| Conjugation | Unconjugated |
| Storage | Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Ambient |
| Gene Name | prospero homeobox 1 |
| Database Link | |
| Background | Prox-1 is a homeobox gene and acts as a master switch for lymphatic endothelial phenotype. Expression of Prox-1 in blood endothelial cells induces expression of other lymphatic marker genes. Together with Podoplanin, Prox-1 can be used to reliably distinguish lymphathic vessels from blood vessels. Prox-1 is expressed in CNS, eye, pancreas, liver and heart, and it is one of the most specific and reliable markers for lymphatic endothelial cells. |
| Synonyms | PROX1 |
| Note | Always centrifuge vials before opening! |
| Reference Data | |
| Protein Categories | Growth Factors, Intracellular Proteins, Transciption Factors |
Reviews
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Citations
Pax6 is essential for lens fiber cell differentiation
Shaham, Smith, Robinson et al
Development (2009) 136 (15), 2567-78 DOI: 10.1242/dev.032888
Shaham, Smith, Robinson et al
Development (2009) 136 (15), 2567-78 DOI: 10.1242/dev.032888
Cited by 131
AI Summary: OriGene products contributed to this study by providing the Pax6 (OriGene: sc-81395) and Sox2 (OriGene: sc-17320) antibodies, which were used for immunohistochemistry and protein detection to assess the roles of these transcription factors in lens fiber cell differentiation.
Showing 1-1 of 1 papers.
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