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FGF2 (NM_002006) Human Recombinant Protein

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SKU
TP750002
Recombinant protein of human Fibroblast Growth Factor-basic (FGF2) produced in E. coli
Size:
100 ug
  $540.00
4 Weeks*
Bulk/Customize

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Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence encoding the region (Gly132-Ser288) of human FGF2
Tag Tag Free
Predicted MW 17.4 kDa
Concentration >0.1 µg/µL as determined by microplate BCA method
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Lyophilized from a sterile solution containing 10 mM Tris-HCl, pH7.5, 150 mM NaCl，8% trehalose
Bioactivity Measured in a cell proliferation assay using 3T3 cells. ED50 for this effect is typically 0.07-0.10 ng/ml.
Cell culture factor (PMID: 26253201)
Cell culture factor (PMID: 26704449)
Cell culture factor (PMID: 29416007)
Cell culture factor (PMID: 29937202)
Cell culture factor (PMID: 29948854)
Endotoxin < 0.1 EU per 1 µg of the protein by the LAL
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -20°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Ambient
Reference Data
RefSeq NP_001997
Locus ID 2247
UniProt ID P09038
Cytogenetics 4q28.1
RefSeq Size 6803
RefSeq ORF 864
Synonyms BFGF; FGF-2; FGFB; HBGF-2
Summary The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. provided by RefSeq, Jul 2008
Protein Categories Chemokines, Cytokines, Growth Factors, Intracellular Proteins, Secreated Proteins
Protein Families Druggable Genome, Secreted Protein
Protein Pathways MAPK signaling pathway, Melanoma, Pathways in cancer, Regulation of actin cytoskeleton
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Documents
Resources
Other "FGF2" proteins (5)
SKU Description Size Price
PH317426 FGF2 MS Standard C13 and N15-labeled recombinant protein (NP_001997) 10 ug
$3,360.00
LC400733 Lyophilized FGF2 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY400733 Transient overexpression lysate of fibroblast growth factor 2 (basic) (FGF2) (as WB positive control) 100 ug
$436.00
TP317426 Recombinant protein of human fibroblast growth factor 2 (basic) (FGF2), 20 µg 20 ug
$867.00
TP723719 Purified recombinant protein of Human fibroblast growth factor 2 (basic) (FGF2) 10 ug
$235.00

file-alt Citations

CDK8 regulates definitive endoderm commitment through cAMP-lysosomal homeostasis and neuroectodermal suppression
Xian, Huang, Bao et al
Cell Death and Disease (2026)
AI Summary: In this study, OriGene’s bFGF (TP750002) was used to induce hepatoblast differentiation from foregut endoderm cells, supporting experiments that revealed CDK8’s role in regulating endodermal commitment and suppressing neuroectodermal fate.
Snippet: At Stage 2 (S2), to induce hepatoblast differentiation, foregut endoderm cells were cultured for 4 days in RPMI 1640 medium containing B-27 without vitamin A, 20 ng/mL KGF, 20 ng/mL BMP2A (Sino Biological, 10426- HNAE1), 100 ng/mL BMP4 (Stemimmune LLC, HST-B4-0100), 10 ng/mL bFGF (Origene, TP750002), and 10 μM Y27632
p53 safeguards chemical reprogramming of human somatic cells toward pluripotency
Cheng, Wang, Yang et al
Cell (2026)
Cited by 6
AI Summary: In this study, OriGene’s Recombinant Human FGF2 (bFGF) (Cat# TP750002) was used as a key growth factor to support the chemical reprogramming of human somatic cells toward pluripotency, enabling investigation of p53’s role in the process.
Snippet: WUXI APPTEC N/A Recombinant Human FGF2 (bFGF) Origene Cat# TP750002 JNKIN8 (J) Selleckchem Cat# S4901 Recombinant Human Heregulinβ-1 (HRG) PEP
Non-gene-edited neural stem cells reverse neuroinflammation and microbiota dysbiosis in a sprague-dawley rat model of autism spectrum disorder
Liu, Wu, Li et al
Transl Psychiatry (2026)
Cited by 1
AI Summary: OriGene's recombinant Human bFGF (TP750002) was used in this study to support the culture and differentiation of neural stem cells, which were central to investigating therapeutic effects in an autism spectrum disorder rat model.
Snippet: nant Human bFGF (Origene, TP750002), and the following small molecules: 5 µM CHIR99021, 10 µM 616452, 2 µM TTNPB, 0.5 µM SAG, 0.5 µM JNKIN8, 2 µM EPZ5676, 0.2 µM DZNep, 1 µM R
3D post-implantation co-culture of human embryo and endometrium
Song, Zhao, Zhang et al
Cell Stem Cell (2026) 33 (1), 58-72.e7 DOI: 10.1016/j.stem.2025.12.002
Cited by 29
AI Summary: OriGene's FGF2 (catalog number TP750002) was used as a key growth factor in the 3D co-culture system to support endometrial organoid and human embryo development in this study.
Snippet: EGF Peprotech AF-100-15 FGF2 Origene TP750002 WNT-3A Proteintech HZ-1296 R-Spondin-1 Peprotech 120-38
Molecular landscape, subtypes, and therapeutic vulnerabilities of central nervous system solitary fibrous tumors
Zhao, Hu, Guan et al
Nat Commun (2025) 16 (1), 7870 DOI: 10.1038/s41467-025-63039-4
Cited by 6
Snippet: …Transcriptomic analysis further classified CNS SFTs into four molecular subtypes: Classical, characterized by cystic necrosis and representing the predomina;supplemented with 10% fetal bovine serum (Gibco, 16000044), 20 ng/mL EGF (Novoprotein, C029-500 μg), 20 ng/mL bFGF (ORIGENE, TP750002), and 1% penicillin/streptomycin (Solarbio, P8420/S8290). …
FigureFigureFigure
Chemical reprogramming of human blood cells to pluripotent stem cells
Peng, Wang, Cheng et al
Cell Stem Cell (2025) 32 (8), 1192-1199.e11 DOI: 10.1016/j.stem.2025.07.003
Cited by 16
AI Summary: OriGene’s Recombinant Human FGF2 (bFGF) (Cat# TP750002) was used in this study to support the chemical reprogramming of human blood cells into pluripotent stem cells.
Snippet: Y-27632 Selleck Cat# S1049 SAG Selleck Cat# S777905 Recombinant Human FGF2 (bFGF) Origene Cat# TP750002 JNK-IN-8 Selleckchem Cat# S4901 Recombinant Human Heregulinβ-1 PEPROTECH Cat# 100-03
Showing 1-6 of 27 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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