CSB (ERCC6) (NM_000124) Human Recombinant Protein
SKU
TP319020
Recombinant protein of human excision repair cross-complementing rodent repair deficiency, complementation group 6 (ERCC6), 20 µg
$867.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 168.2 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_000115 |
| Locus ID | 2074 |
| UniProt ID | Q03468 |
| Cytogenetics | 10q11.23 |
| RefSeq Size | 8993 |
| RefSeq ORF | 4479 |
| Synonyms | ARMD5; CKN2; COFS; COFS1; CSB; CSB-PGBD3; POF11; RAD26; UVSS1 |
| Summary | This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The encoded protein has ATP-stimulated ATPase activity, interacts with several transcription and excision repair proteins, and may promote complex formation at DNA repair sites. Mutations in this gene are associated with Cockayne syndrome type B and cerebrooculofacioskeletal syndrome 1. Alternative splicing occurs between a splice site from exon 5 of this gene to the 3' splice site upstream of the open reading frame (ORF) of the adjacent gene, piggyback-derived-3 (GeneID:267004), which activates the alternative polyadenylation site downstream of the piggyback-derived-3 ORF. The resulting transcripts encode a fusion protein that shares sequence with the product of each individual gene. provided by RefSeq, Mar 2016 |
| Protein Families | Druggable Genome |
| Protein Pathways | Nucleotide excision repair |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "CSB" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH319020 | ERCC6 MS Standard C13 and N15-labeled recombinant protein (NP_000115) | 10 ug |
$3,360.00
|
|
| LC424915 | Lyophilized ERCC6 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY424915 | Transient overexpression lysate of excision repair cross-complementing rodent repair deficiency, complementation group 6 (ERCC6) (as WB positive control) | 100 ug |
$665.00
|
|
Citations
PARP1 and PARylation facilitate transcription-coupled DNA repair by stabilizing the CSB-RNAPII complex
Robu, Shah, van den Heuvel et al
Nucleic Acids Res (2025) 53 (22) DOI: 10.1093/nar/gkaf1303
Robu, Shah, van den Heuvel et al
Nucleic Acids Res (2025) 53 (22) DOI: 10.1093/nar/gkaf1303
Cited by 5
AI Summary: OriGene’s recombinant human CSB protein (TP319020) was used in vitro to study the molecular interactions underpinning the stabilization of the CSB-RNAPII complex during transcription-coupled DNA repair.
Snippet: In vitro: We used recombinant human CSB (Origene, TP319020) and its fragments [61], recombinant automodified human PARP1 (Tulip, BioLabs, 2095), human PARP1 (;Laemmeli (LB) sample buffer. The same protocol was followed for performing immunoprecipitation of endogenous PARP1 in HEK expressing GFP-CSB or its fragments. In vitro: We used recombinant human CSB (Origene, TP319020) and its fragments [61], recombinant automodified human PARP1 (Tulip, BioLabs, 2095), human PARP1 (Enzo Life Sciences, ALX-201-063 and [62] and its fragments: 1–327 (Creative Bioma
The ARK2N-CK2 complex initiates transcription-coupled repair through enhancing the interaction of CSB with lesion-stalled RNAPII
Luo, Li, Li et al
Proc Natl Acad Sci U S A (2024) 121 (24), e2404383121 DOI: 10.1073/pnas.2404383121
Luo, Li, Li et al
Proc Natl Acad Sci U S A (2024) 121 (24), e2404383121 DOI: 10.1073/pnas.2404383121
Cited by 12
AI Summary: OriGene’s CSB protein was used in this study for in vitro experiments to investigate the interaction and phosphorylation between CSB and MBP-ARK2N, helping to elucidate the molecular mechanism of transcription-coupled repair.
Snippet: (E) CSB protein bought in Origene and MBP-ARK2N protein purified in yeast were stained by Coomassie blue. (F) CSB and MBP-ARK2N proteins were incubated in vitro,
Showing 1-2 of 2 papers.
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