iNOS (NOS2) (NM_000625) Human Recombinant Protein
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 130.9 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_000616 |
| Locus ID | 4843 |
| UniProt ID | P35228 |
| Cytogenetics | 17q11.2 |
| RefSeq Size | 4221 |
| RefSeq ORF | 3459 |
| Synonyms | HEP-NOS; INOS; NOS; NOS2A |
| Summary | Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. provided by RefSeq, Jul 2008 |
| Protein Categories | Cancer: Gastrointestinal, Cytokines, Intracellular Proteins |
| Protein Families | Druggable Genome |
| Protein Pathways | Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Arginine and proline metabolism, Calcium signaling pathway, Long-term depression, Metabolic pathways, Pathways in cancer, Small cell lung cancer |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "iNOS" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH311819 | NOS2 MS Standard C13 and N15-labeled recombinant protein (NP_000616) | 10 ug |
$3,360.00
|
|
| LC400213 | Lyophilized NOS2 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY400213 | Transient overexpression lysate of nitric oxide synthase 2, inducible (NOS2) (as WB positive control) | 100 ug |
$665.00
|
|
Citations
iNOS modulates inflammatory responses in an NO-independent manner through direct interaction with IRG1 in mitochondria
Diotallevi, Outeiral, Patel et al
Nat Metab (2026) 8 (4), 855-868 DOI: 10.1038/s42255-026-01492-1
Diotallevi, Outeiral, Patel et al
Nat Metab (2026) 8 (4), 855-868 DOI: 10.1038/s42255-026-01492-1
Cited by 6
AI Summary: In this study, OriGene's human iNOS protein (catalog number TP311819) was used to investigate and confirm the direct interaction between iNOS and IRG1 in mitochondria, elucidating a novel, NO-independent role of iNOS in modulating inflammatory responses.
Snippet: the iNOS chip. Moreover, to confirm binding specificity, BSA (10 µg ml−1) was included as a negative control. Mouse iNOS was acquired from Cayman chemicals (60864), human iNOS from Origene (TP311819) and both human and mouse IRG1 were purified as previously described (see ‘Purification of Mouse Irg1’).Blue native gelsCel
Showing 1-1 of 1 papers.
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