IPMK (NM_152230) Human Recombinant Protein
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 47 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_689416 |
| Locus ID | 253430 |
| UniProt ID | Q8NFU5 |
| Cytogenetics | 10q21.1 |
| RefSeq Size | 6133 |
| RefSeq ORF | 1248 |
| Summary | This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role in nuclear mRNA export. Pseudogenes of this gene are located on the long arm of chromosome 13 and the short arm of chromosome 19. provided by RefSeq, Dec 2010 |
| Protein Categories | Intracellular Proteins |
| Protein Pathways | Inositol phosphate metabolism |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "IPMK" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH309343 | IPMK MS Standard C13 and N15-labeled recombinant protein (NP_689416) | 10 ug |
$3,360.00
|
|
| LC407707 | Lyophilized IPMK HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY407707 | Transient overexpression lysate of inositol polyphosphate multikinase (IPMK) (as WB positive control) | 100 ug |
$436.00
|
|
Citations
Phytic acid (InsP6) activates HDAC3 epigenetic axis to maintain intestinal barrier function
Chatterjee, Sin, Tran et al
Nat Commun (2026)
Chatterjee, Sin, Tran et al
Nat Commun (2026)
Cited by 8
Inositol Hexaphosphate (InsP6) Activates the HDAC1/3 Epigenetic Axis to Maintain Intestinal Barrier Function
Chatterjee, Preval, Sin et al
bioRxiv (2024)
Chatterjee, Preval, Sin et al
bioRxiv (2024)
Cited by 6
Snippet: pMX-IPMK-WT-myc and pMX-IPMK-KSA-myc plasmids transiently transfected into IPMK-KO HCT 116 cells using Lipofectamine 3000 (Cat no. L3000001, Thermo Scientific) according to the manufacturer protocol. Recombinant myc-IPMK was purchased from Origene, (Cat #: TP309343) while recombinant GST-HDAC1 (Cat #: H83-30G), GST-HDAC3 (Cat #: H85-30G) and GST (Cat #: G52-30U) were purchased from Signal Chem
Identification of Small-Molecule Inhibitors of Human Inositol Hexakisphosphate Kinases by High-Throughput Screening
Liao, Ye, Heitmann et al
ACS Pharmacol Transl Sci (2021) 4 (2), 780-789 DOI: 10.1021/acsptsci.0c00218
Liao, Ye, Heitmann et al
ACS Pharmacol Transl Sci (2021) 4 (2), 780-789 DOI: 10.1021/acsptsci.0c00218
Cited by 32
AI Summary: OriGene products contributed to this study by providing the human IP6K1 cDNA clone (Cat# RC200598) used for protein expression and functional assays to identify and validate small-molecule inhibitors of IP6K1.
Identification of Small-Molecule Inhibitors of Human Inositol Hexakisphosphate Kinases by High-Throughput Screening
Liao, Ye, Heitmann et al
ACS Pharmacol. Transl. Sci. (2021)
Liao, Ye, Heitmann et al
ACS Pharmacol. Transl. Sci. (2021)
Cited by 32
AI Summary: In this study, the researchers used human recombinant IPMK (OriGene, catalog no. TP309343) to determine IC50 values and characterize inhibitor selectivity, contributing to the identification of small-molecule inhibitors of inositol hexakisphosphate kinases.
Snippet: 1 with some variations. The IP6K2 assays used 7.5 nM enzyme, and the IP6K3 assays used 120 nM enzyme with a 2 h reaction time. IC50 DETERMINATION FOR IPMK Human recombinant IPMK was purchased from Origene (catalog no. TP309343). d-Myo-Iinositol-1,4,5,6-tetraphosphate (IP4) was purchased from Caymen Chem (catalog no. 10007783). The _K_m’s for IP4 and ATP were determined to be 5.6 and 10 μM, r
IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration
Guha, Tyagi, Chowdhury et al
Cell Rep (2019) 26 (10), 2692-2703.e7 DOI: 10.1016/j.celrep.2019.02.013
Guha, Tyagi, Chowdhury et al
Cell Rep (2019) 26 (10), 2692-2703.e7 DOI: 10.1016/j.celrep.2019.02.013
Cited by 50
AI Summary: In this study, OriGene’s IPMK shRNA (OriGene, #TL315508) and IPMK cDNA (OriGene, #RC210508) products were used to manipulate IPMK expression in cell lines, enabling the authors to investigate IPMK’s role in autophagy regulation and liver regeneration.
Showing 1-5 of 5 papers.
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