PABP (PABPC1) (NM_002568) Human Recombinant Protein
$867.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 70.5 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_002559 |
| Locus ID | 26986 |
| UniProt ID | P11940 |
| Cytogenetics | 8q22.3 |
| RefSeq Size | 2869 |
| RefSeq ORF | 1908 |
| Synonyms | PAB1; PABP; PABP1; PABPC2; PABPL1 |
| Summary | This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.provided by RefSeq, Aug 2010 |
| Protein Categories | Intracellular Proteins |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "PABP" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH307354 | PABPC1 MS Standard C13 and N15-labeled recombinant protein (NP_002559) | 10 ug |
$3,360.00
|
|
| LC419240 | Lyophilized PABPC1 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY419240 | Transient overexpression lysate of poly(A) binding protein, cytoplasmic 1 (PABPC1) (as WB positive control) | 100 ug |
$436.00
|
|
Citations
Functional atlas of vertebrate viral RNA elements that stabilize RNA and enhance translation
Seo, Lee, Lim et al
Cell (2026)
Seo, Lee, Lim et al
Cell (2026)
Cited by 1
The functionally conserved human lncRNA motif GULF lowers glucose and lipid levels in obese mice
Li, Seok, Jiang et al
J Clin Invest (2025) 135 (18) DOI: 10.1172/JCI186355
Li, Seok, Jiang et al
J Clin Invest (2025) 135 (18) DOI: 10.1172/JCI186355
AI Summary: OriGene’s recombinant c-Myc–tagged CRTC2 protein (catalog TP307354) was used in RNA-protein binding assays to investigate the interaction between GULL lncRNAs and CRTC2 in this study.
Snippet: fic) per the manufacturer’s instructions. RNA dot blot and competition assay One microgram biotinylated h/mGULL was incubated with 50 ng recombinant c-Myc–tagged CRTC2 proteins (catalog TP307354, OriGene Technologies) in RNA-protein binding buffer (50 mM Tris-HCl [pH 7.9], 10 mM β-mercaptoethanol, 10% glycerol, 5 mM MgCl2, 100 mM KCl, 0.1% NP-40, 10 mg/mL yeast transfer RNA, 40 U/μL RNase in
Systemic identification of functionally conserved lncRNA metabolic regulators in human and mouse livers
Jiang, Li, Seok et al
Gastroenterology (2025)
Jiang, Li, Seok et al
Gastroenterology (2025)
Cited by 6
PABP Cooperates with the CCR4-NOT Complex to Promote mRNA Deadenylation and Block Precocious Decay
Yi, Park, Ha et al
Mol. Cell (2018) 70 (6), 1081-1088.e5 DOI: 10.1016/j.molcel.2018.05.009
Yi, Park, Ha et al
Mol. Cell (2018) 70 (6), 1081-1088.e5 DOI: 10.1016/j.molcel.2018.05.009
AI Summary: OriGene’s recombinant PABPC1 protein was used in this study to investigate how PABP interacts with deadenylase complexes and influences mRNA deadenylation and stability.
Snippet: Multiple deadenylases are known in vertebrates, the PAN2-PAN3 (PAN2/3) and CCR4-NOT (CNOT) complexes, and PARN, yet their differential functions remain ambiguo.;RNA substrates and recombinant PABPC1 (Origene) were incubated for 30 min at 37°C in IVD buffer. … RNA-PABP complexes were separated at 4°C on 6% native polyacrylamide gels containing 20% glycerol. …
Uridylation by TUT4 and TUT7 Marks mRNA for Degradation
Lim, Ha, Chang et al
Cell (2014) 159 (6), 1365-76 DOI: 10.1016/j.cell.2014.10.055
Lim, Ha, Chang et al
Cell (2014) 159 (6), 1365-76 DOI: 10.1016/j.cell.2014.10.055
Cited by 315
AI Summary: OriGene’s recombinant human PABPC1 protein (TP307354) was used in uridylation assays to investigate how PABPC1 influences TUT7-mediated mRNA uridylation and degradation in this study.
Snippet: … For uridylation assay in the presence of PABPC1, 10–40 nM of recombinant human PABPC1 (Origene, TP307354) was preincubated with RNA for 10 min and then uridylation was carried out by adding 160 nM of recombinant TUT7 (951–1,495 aa). Buffer D with final 300 mM KCl was used when uridylation assay was carried out in the presence of PABPC1. …
CELF1 is an EIF4E binding protein that promotes translation of epithelial-mesenchymal transition effector mRNAs
Chaudhury, Pal, Kongchan et al
bioRxiv (2019)
Chaudhury, Pal, Kongchan et al
bioRxiv (2019)
Showing 1-6 of 7 papers.
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