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Pgm3 Mouse shRNA Lentiviral Particle (Locus ID 109785)

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SKU
TL505905V
Pgm3 - Mouse shRNA lentiviral particles (4 unique 29mer target-specific shRNA, 1 scramble control), 0.5 ml each, >10^7 TU/ml.
  $1,731.00
5 Weeks*

Frequently Bought Together (2)

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TR30021V Control Lenti particles, Scrambled shRNA, Expressing GFP and Puro, 1x10^7 TU/ml, 0.5 ml
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Other products for "Pgm3 or NM_001163746"

Specifications
Specifications
Product Data
Locus ID 109785
Synonyms 2810473H05Rik; Agm1; BB187688; C77933; PAGM; Pgm-3
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral particles
Components Pgm3 - Mouse shRNA lentiviral particles (4 unique 29mer target-specific shRNA, 1 scramble control), 0.5 ml each, >10^7 TU/ml.
RefSeq NM_001163746, NM_028352, NM_001163746.1, NM_028352.1, NM_028352.2, NM_028352.3, NM_028352.4, BC138700
UniProt ID Q9CYR6
Summary Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Performance Guaranteed OriGene guarantees that the sequences in the shRNA expression cassettes are verified to correspond to the target gene with 100% identity. One of the four constructs at minimum are guaranteed to produce 70% or more gene expression knock-down provided a minimum transfection efficiency of 80% is achieved. Western Blot data is recommended over qPCR to evaluate the silencing effect of the shRNA constructs 72 hrs post transfection. To properly assess knockdown, the gene expression level from the included scramble control vector must be used in comparison with the target-specific shRNA transfected samples.

For non-conforming shRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the shRNA kit. To arrange for a free replacement with newly designed constructs, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled shRNA control (Western Blot data preferred).
Storage Store at -80°C
Shipping Dry Ice
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Documents
Resources

file-alt Citations

Hyperglycosylation is a metabolic driver of Alzheimer's disease
Hawkinson, Liu, Ribas et al
Nat Metab (2026) 8 (6), 1410-1425 DOI: 10.1038/s42255-026-01538-4
Cited by 16
AI Summary: OriGene products contributed to this paper by providing the shPGM3 lentivirus (TL505905V) for targeted knockdown of glycan biosynthetic enzymes and the shScrambled control lentivirus (TR30021V), which were used in stereotaxic injections to investigate the role of glycan metabolism in Alzheimer's disease mouse models.
Snippet: 2 weeks.Lentiviral delivery and stereotaxic injectionsTo knock down glycan biosynthesis, short hairpin RNA targeting PGM3 (shPGM3, TL505905V;Origene) or control shScrambled lentivirus (TR30021V;Origene) was bilaterally injected into the lateral ventricles of WT, 5xFAD and PS19 mice. Injections were performed using a stereotaxic frame at c
FigureFigureFigure
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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